Introduction：Basic information about CAS 5168-36-5|5-Hydroxy-2'-deoxyuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Hydroxy-2'-deoxyuridine |
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| CAS Number | 5168-36-5 | Molecular Weight | 244.20100 |
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| Density | 1.698g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H12N2O6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-hydroxy-2'-deoxyuridine |
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| Synonym | More Synonyms |
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5-Hydroxy-2'-deoxyuridine BiologicalActivity
| Description | 5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase[1]. |
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| Related Catalog | Research Areas >>Others |
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| Target | Human Endogenous Metabolite |
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| In Vitro | To study the specificity of nucleotide incorporation opposite 5-hydroxypyrimidines in template DNA, 18- and 45-member oligodeoxyribonucleotides, containing an internal 2'-deoxy-5-hydroxyuridine (5-OHdU) in two different sequence contexts, were used. Translesion synthesis past 2'-deoxy-5-hydroxyuridine (5-OHdU) in both oligonucleotides occurred, but pauses both opposite, and one nucleotide prior to, the modified base in the template is observed. The specificity of nucleotide incorporation opposite 2'-deoxy-5-hydroxyuridine (5-OHdU) in the template is sequence context dependent. In one sequence context, dA is the principal nucleotide incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU). However in a second sequence context, dC is the predominant base incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU). In that same sequence context, dC is also the predominant nucleotide incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU)[1]. |
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| References | [1]. Purmal AA, et al. Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro. Nucleic Acids Res. 1994 Jan 11;22(1):72-8. |
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Chemical & Physical Properties
| Density | 1.698g/cm3 |
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| Molecular Formula | C9H12N2O6 |
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| Molecular Weight | 244.20100 |
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| Exact Mass | 244.07000 |
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| PSA | 124.78000 |
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| Index of Refraction | 1.654 |
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| InChIKey | UIJSURSVLVISBO-UBKIQSJTSA-N |
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| SMILES | O=c1[nH]c(=O)n(C2CC(O)C(CO)O2)cc1O |
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| Storage condition | 2-8°C |
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Synonyms
| Uridine,2'-deoxy-5-hydroxy |
| 2'-Deoxy-5-hydroxyuridine |
| Oh-5-du |
