CAS 54187-04-1|Rilmenidine

Introduction：Basic information about CAS 54187-04-1|Rilmenidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Rilmenidine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Rilmenidine
CAS Number	54187-04-1	Molecular Weight	180.247
Density	1.5±0.1 g/cm3	Boiling Point	355.5±9.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₆N₂O	Melting Point	106 - 107ºC
MSDS	/	Flash Point	168.8±18.7 °C

Names

Name	N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
Synonym	More Synonyms

Rilmenidine BiologicalActivity

Description	Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Imidazoline ReceptorSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Imidazoline ReceptorSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
In Vitro	Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[2]. Cell Viability Assay[2] Cell Line: K562 cells Concentration: 25, 50, 100 μM Incubation Time: 24 hours Result: Dose-dependently inhibited K562 colony formation.
In Vivo	Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[3].
References	[1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [2]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180. [3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	355.5±9.0 °C at 760 mmHg
Melting Point	106 - 107ºC
Molecular Formula	C₁₀H₁₆N₂O
Molecular Weight	180.247
Flash Point	168.8±18.7 °C
Exact Mass	180.126266
PSA	33.62000
LogP	0.57
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.711
InChIKey	CQXADFVORZEARL-UHFFFAOYSA-N
SMILES	C1COC(NC(C2CC2)C2CC2)=N1
Storage condition	Store at -20°C
Water Solubility	H2O: 7.3 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP7207400

CHEMICAL NAME :: Oxazolidine, 2-((dicyclopropylmethyl)imino)-

CAS REGISTRY NUMBER :: 54187-04-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H16-N2-O

MOLECULAR WEIGHT :: 180.28

WISWESSER LINE NOTATION :: T5N CO AUTJ BMY- AL3TJ&- AL3TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 umol/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,527,1983

Safety Information

Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	RP7207400
HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-

Rilmenidine

S 3341-3

S 3341

N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine

Oxaminozoline

hyperium

N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine

2-[N-(Dicyclopropylmethyl)amino]oxazoline

EINECS 259-021-0

Tenaxum

MFCD00865924

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