CAS 115-46-8|Azacyclonol

Introduction：Basic information about CAS 115-46-8|Azacyclonol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Azacyclonol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Azacyclonol
CAS Number	115-46-8	Molecular Weight	267.365
Density	1.1±0.1 g/cm3	Boiling Point	445.5±40.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₁NO	Melting Point	160-163 °C
MSDS	/	Flash Point	142.0±18.0 °C

Names

Name	Diphenyl(piperidin-4-yl)methanol
Synonym	More Synonyms

Azacyclonol BiologicalActivity

Description	Azacyclonol, also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.Target: OthersAzacyclonol is a drug which is a so-called ataractive, or agent which diminishes hallucinations in psychotic individuals. The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver [1]. The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1 [2]. The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing [3].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Raeissi, S.D., et al., Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine. Pharm Res, 1997. 14(8): p. 1019-25. [2]. Ling, K.H., et al., Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. Drug Metab Dispos, 1995. 23(6): p. 631-6. [3]. Brown, D.A. and J.P. Quilliam, The effects of some centrally acting drugs on ganglionic transmission in the cat. Br J Pharmacol Chemother, 1964. 23(2): p. 241-56.

Description

Azacyclonol, also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.Target: OthersAzacyclonol is a drug which is a so-called ataractive, or agent which diminishes hallucinations in psychotic individuals. The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver [1]. The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1 [2]. The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing [3].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Raeissi, S.D., et al., Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine. Pharm Res, 1997. 14(8): p. 1019-25.

[2]. Ling, K.H., et al., Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. Drug Metab Dispos, 1995. 23(6): p. 631-6.

[3]. Brown, D.A. and J.P. Quilliam, The effects of some centrally acting drugs on ganglionic transmission in the cat. Br J Pharmacol Chemother, 1964. 23(2): p. 241-56.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	445.5±40.0 °C at 760 mmHg
Melting Point	160-163 °C
Molecular Formula	C₁₈H₂₁NO
Molecular Weight	267.365
Flash Point	142.0±18.0 °C
Exact Mass	267.162323
PSA	32.26000
LogP	3.25
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.584
InChIKey	ZMISODWVFHHWNR-UHFFFAOYSA-N
SMILES	OC(c1ccccc1)(c1ccccc1)C1CCNCC1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN0470000

CHEMICAL NAME :: 4-Piperidinemethanol, alpha,alpha-diphenyl-

CAS REGISTRY NUMBER :: 115-46-8

BEILSTEIN REFERENCE NO. :: 0230221

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H21-N-O

MOLECULAR WEIGHT :: 267.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

Safety Information

Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RTECS	TN0470000
HS Code	29333999

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

alpha,alpha-Diphenyl-4-piperidinomethanol

4-(α,α Diphenyl) piperidine methanol

Diphenyl(4-piperidinyl)methanol

a,a-Diphenyl-4-piperidinemethanol

γ-Pipradrol

MFCD00066980

Ataractan

4-Piperidinemethanol, α,α-diphenyl-

α,α-Diphenyl-4-piperidinemethanol

α-(4-Piperidyl)benzhydrol

azacyclonol

diphenyl(4-piperidyl)methanol

Psychosan

g-Pipradrol

diphenyl(piperidin-4-yl)methanol

α,α-Diphenyl-4-piperidinomethanol

Diphenyl (g-Pyridyl)carbinol

a-(4-Piperidyl)benzhydrol

4-(Diphenylhydroxymethyl)piperidine

EINECS 204-092-5

Calmeran

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