Introduction：Basic information about CAS 5983-09-5|2',3'-Dideoxyuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2',3'-Dideoxyuridine |
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| CAS Number | 5983-09-5 | Molecular Weight | 212.20 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H12N2O4 | Melting Point | 127-129 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | 2',3'-Dideoxyuridine |
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| Synonym | More Synonyms |
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2',3'-Dideoxyuridine BiologicalActivity
| Description | 2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Melting Point | 127-129 °C(lit.) |
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| Molecular Formula | C9H12N2O4 |
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| Molecular Weight | 212.20 |
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| Exact Mass | 226.095352 |
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| PSA | 84.32000 |
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| LogP | -0.76 |
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| Index of Refraction | 1.552 |
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| InChIKey | BTOTXLJHDSNXMW-POYBYMJQSA-N |
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| SMILES | O=c1ccn(C2CCC(CO)O2)c(=O)[nH]1 |
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| Storage condition | 2~8°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | C |
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| Risk Phrases | 34-36/37 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles10
More Articles
| Abacavir and metabolite pharmacokinetics in HIV-1-infected children and adolescents. J. Acquir. Immune Defic. Syndr. 51(1) , 54-9, (2009) Abacavir (ABC) oral clearance, adjusted for body size, is approximately 2 times higher for children than adults with a corresponding difference in dose regimens. However, there are limited data availa... | |
| Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate. Mol. Pharmacol. 37(2) , 157-63, (1990) 2',3'-Dideoxyuridine (ddUrd) exhibits poor if any anti-human immunodeficiency virus (HIV) activity in ATH8 and MT-4 cells. This is in agreement with the failure of ddUrd to be efficiently anabolized i... | |
| Glycosyl-oxycarbonylaminosulfonyl-2',3'-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity. Bioorg. Med. Chem. 1(4) , 279-84, (1993) Several lipophilic-2',3'-dideoxynucleotide analogues have been synthesized and tested against Human Immunodeficiency Virus (HIV). Glycosyl-oxycarbonylaminosulfonyl-analogues of 3'-deoxythymidine and 2... | |
Synonyms
| 1-[5-(Hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione |
| 1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione |
| 1-[(2R,5S)-5-(Hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione |
| 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]- |
| 2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[tetrahydro-5-(hydroxymethyl)-2-furanyl]- |
| MFCD00013359 |
| 1-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione |
| 1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
