CAS 545-48-2|Erythrodiol
| Common Name | Erythrodiol | ||
|---|---|---|---|
| CAS Number | 545-48-2 | Molecular Weight | 442.717 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 520.5±50.0 °C at 760 mmHg |
| Molecular Formula | C30H50O2 | Melting Point | 230-231ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 209.9±24.7 °C |
Names
| Name | erythrodiol |
|---|---|
| Synonym | More Synonyms |
Erythrodiol BiologicalActivity
| Description | Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis[1]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic Disease |
| In Vitro | Erythrodiol (1-15 μM; 24 hours) enhances ABCA1 protein level in a concentration-dependent manner, and reachs significance at 10 and 15 μM[1]. Western Blot Analysis[1] Cell Line: THP-1 macrophage cells Concentration: 1 μM, 2.5 μM, 5 μM, 10 μM, and 15 μM Incubation Time: 24 hours Result: Increased ABCA1 protein expression. |
| References | [1]. Wang L, et al. Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Front Pharmacol. 2017 Jun 13;8:375. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 520.5±50.0 °C at 760 mmHg |
| Melting Point | 230-231ºC(lit.) |
| Molecular Formula | C30H50O2 |
| Molecular Weight | 442.717 |
| Flash Point | 209.9±24.7 °C |
| Exact Mass | 442.381073 |
| PSA | 40.46000 |
| LogP | 9.18 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.551 |
| InChIKey | PSZDOEIIIJFCFE-OSQDELBUSA-N |
| SMILES | CC1(C)CCC2(CO)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC43C)C2C1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R22 |
| Safety Phrases | 2-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles22
More Articles| Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta. Br. J. Nutr. 92(4) , 635-42, (2004) 'Orujo' olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological prop... | |
| Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector. J. AOAC Int. 95(6) , 1720-4, (2012) Mixing of refined olive-pomace oil with virgin olive oil is a fraud that has been tried often. Normally, the tests that detected the fraud were determinations of wax esters, erythrodiol+uvaol, and sti... | |
| Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells. Cytokine 36(5-6) , 211-7, (2006) Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption. Maslinic acid, oleanolic acid, erythrodiol, and uvaol are pentacycl... |
Synonyms
| Olean-12-ene-3,28-diol, (3β)- |
| HOMOOLESTRANOL |
| olean-12-ene-3,28-diol |
| MFCD00017294 |
| (3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(Hydroxyméthyl)-4,4,6a,6b,11,11,14b-heptaméthyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picénol |
| Erythrodiol |
| (3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(Hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picenol |
| (3β)-Olean-12-ene-3,28-diol |
| EINECS 208-890-4 |
| Olean-12-ene-3β,28-diol |
| 12-OLEANENE-3,28-DIOL |
| (3β)-Olean-12-ène-3,28-diol |
| ERYTHODIOL |
| Oleanolic alcohol |
