CAS 112-35-6|m-PEG3-OH
| Common Name | m-PEG3-OH | ||
|---|---|---|---|
| CAS Number | 112-35-6 | Molecular Weight | 164.199 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 233.9±20.0 °C at 760 mmHg |
| Molecular Formula | C7H16O4 | Melting Point | -44ºC |
| MSDS | ChineseUSA | Flash Point | 95.3±21.8 °C |
Names
| Name | triethylene glycol monomethyl ether |
|---|---|
| Synonym | More Synonyms |
m-PEG3-OH BiologicalActivity
| Description | m-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 233.9±20.0 °C at 760 mmHg |
| Melting Point | -44ºC |
| Molecular Formula | C7H16O4 |
| Molecular Weight | 164.199 |
| Flash Point | 95.3±21.8 °C |
| Exact Mass | 164.104858 |
| PSA | 47.92000 |
| LogP | -1.51 |
| Vapour density | 5.66 (vs air) |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.427 |
| InChIKey | JLGLQAWTXXGVEM-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCO |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,634,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,634,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11300 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 7100 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0892 No. of Facilities: 13261 (estimated) No. of Industries: 85 No. of Occupations: 32 No. of Employees: 80404 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0892 No. of Facilities: 2416 (estimated) No. of Industries: 22 No. of Occupations: 29 No. of Employees: 18956 (estimated) No. of Female Employees: 9842 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S24/25-S22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | KL6390000 |
| HS Code | 2909499000 |
Customs
| HS Code | 2909499000 |
|---|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
Articles7
More Articles| Core-shell polymer nanoparticles for prevention of GSH drug detoxification and cisplatin delivery to breast cancer cells. Nanoscale 7 , 17964-79, (2015) Platinum drug delivery against the detoxification of cytoplasmic thiols is urgently required for achieving efficacy in breast cancer treatment that is over expressed by glutathione (GSH, thiol-oligope... | |
| Chemical modification of neamine. Oncogene 21(28) , 4462-70, (2002) The aminocyclitol antibiotic neamine has been modified chemically by removing one or two hydroxyl groups from the 2-deoxystreptamine moiety to give 5- and 6- deoxyneamines (5 and 10), as well as 5,6-d... | |
| Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs. Beilstein J. Org. Chem. 10 , 2920-2927, (2014) Methyl and ethyl thioether groups were introduced at all primary positions of α-, β-, and γ-cyclodextrin by nucleophilic displacement reactions starting from the corresponding per-(6-deoxy-6-bromo)cyc... |
Synonyms
| UNII-DN0P4Q4I16 |
| Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)- |
| Triethylene glycol monomethyl ether |
| 3,6,9-Trioxa-1-decanol |
| Triglycol monomethyl ether |
| 2-(2-(2-Methoxyethoxy)ethoxy)ethanol |
| Methoxytriglycol |
| triethylene glycol methyl ether |
| Methoxytriethylene glycol |
| 2-[2-(2-Methoxyethoxy)ethoxy]ethanol |
| Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]- |
| Methyltrioxitol |
| Methyl Triglycol |
| Methyltriglycol |
| MFCD00002875 |
| Methyl triethylene glycol |
| EINECS 203-962-1 |
