CAS 85118-33-8|Gaboxadol hydrochloride
| Common Name | Gaboxadol hydrochloride | ||
|---|---|---|---|
| CAS Number | 85118-33-8 | Molecular Weight | 176.601 |
| Density | / | Boiling Point | 295.7ºC at 760 mmHg |
| Molecular Formula | C6H9ClN2O2 | Melting Point | 236 °C |
| MSDS | USA | Flash Point | 132.6ºC |
Names
| Name | 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol Hydrochloride |
|---|---|
| Synonym | More Synonyms |
Gaboxadol hydrochloride BiologicalActivity
| Description | Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
| Target | GABAA[1] |
| References | [1]. Zanettini C, et al. Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats. Psychopharmacology (Berl). 2016 May;233(10):2005-13. |
Chemical & Physical Properties
| Boiling Point | 295.7ºC at 760 mmHg |
|---|---|
| Melting Point | 236 °C |
| Molecular Formula | C6H9ClN2O2 |
| Molecular Weight | 176.601 |
| Flash Point | 132.6ºC |
| Exact Mass | 176.035248 |
| PSA | 58.03000 |
| LogP | 0.74440 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| RTECS | NY3396800 |
Articles9
More Articles| Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J. Neurosci. 34(31) , 10361-78, (2014) The enteric nervous system (ENS) provides the intrinsic neural control of the gastrointestinal tract (GIT) and regulates virtually all GI functions. Altered neuronal activity within the ENS underlies ... | |
| Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice. Psychopharmacol. Ser. 232(8) , 1415-26, (2015) Allopregnanolone (ALLO) is an endogenous neuroactive steroid thought to alter the reinforcement value of alcohol (ethanol) due to its actions as a positive modulator of the GABAA receptor (GABAAR). Ex... | |
| Effects of gaboxadol on the expression of cocaine sensitization in rats. Exp. Clin. Psychopharmacol. 24 , 131-41, (2016) Behavioral sensitization to psychostimulants is associated with changes in dopamine (DA), glutamate, and GABA within the mesocorticolimbic and nigrostriatal DA systems. Because GABAA receptors are hig... |
Synonyms
| Gaboxadol hydrochloride |
| Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrochloride (1:1) |
| 4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-3(2H)-one hydrochloride (1:1) |
