CAS 122898-67-3|Itopride

Introduction：Basic information about CAS 122898-67-3|Itopride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Itopride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Itopride
CAS Number	122898-67-3	Molecular Weight	358.431
Density	1.1±0.1 g/cm3	Boiling Point	510.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₆N₂O₄	Melting Point	185-187 °C(lit.)
MSDS	/	Flash Point	262.3±30.1 °C

Names

Name	N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide
Synonym	More Synonyms

Itopride BiologicalActivity

Description	Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>AChE
Target	D2 Receptor Acetylcholinesterase
In Vitro	Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3]. Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3].
In Vivo	Itopride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group[4]. Itopride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min[4].
References	[1]. Iwanaga Y, et al. A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 1990 Aug;99(2):401-8. [2]. Kim YS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21;11(27):4210-4. [3]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8. [4]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct;31(10):1917-22.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	510.1±50.0 °C at 760 mmHg
Melting Point	185-187 °C(lit.)
Molecular Formula	C₂₀H₂₆N₂O₄
Molecular Weight	358.431
Flash Point	262.3±30.1 °C
Exact Mass	358.189270
PSA	60.03000
LogP	2.43
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.552
InChIKey	QQQIECGTIMUVDS-UHFFFAOYSA-N
SMILES	COc1ccc(C(=O)NCc2ccc(OCCN(C)C)cc2)cc1OC
Water Solubility	18 g/100 mL (20 ºC)

Safety Information

Hazard Codes	T,Xi,Xn
Risk Phrases	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing .
HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

MFCD00867431

Itopride

Itopride (INN)

UNII-81BMQ80QRL

N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide

Benzamide, N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-

Ganaton

[125I]-Itopride

N-{4-[2-(Dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide

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