CAS 54143-57-6|metoclopramide hydrochloride
Introduction：Basic information about CAS 54143-57-6|metoclopramide hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | metoclopramide hydrochloride | ||
|---|---|---|---|
| CAS Number | 54143-57-6 | Molecular Weight | 354.27 |
| Density | / | Boiling Point | 418.7ºC at 760mmHg |
| Molecular Formula | C14H25Cl2N3O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 207ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | metoclopramide hydrochloride |
|---|---|
| Synonym | More Synonyms |
metoclopramide hydrochloride BiologicalActivity
| Description | Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Endocrinology |
Chemical & Physical Properties
| Boiling Point | 418.7ºC at 760mmHg |
|---|---|
| Molecular Formula | C14H25Cl2N3O3 |
| Molecular Weight | 354.27 |
| Flash Point | 207ºC |
| PSA | 67.59000 |
| LogP | 3.77650 |
| InChIKey | KJBLQGHJOCAOJP-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC.Cl.O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
Articles32
More Articles| Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates. Drug Metab. Pharmacokinet. 29(5) , 419-26, (2014) In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rod... | |
| Clinical challenge. Esophageal hiatal hernia. J. Zoo Wildl. Med. 45(4) , 999-1001, (2014) | |
| The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. Am. J. Gastroenterol. 108(9) , 1382-91, (2013) The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this pap... |
Synonyms
| Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride (9CI) |
| Annavar |
| 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide monohydrochloride |
| 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride |
| Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, hydrochloride (1:1) |
| 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (1:1) |
| Metoclopramide hydrochloride [USAN:JAN] |
| 4-Amino-5-chlor-N-[2-(diethylamino)ethyl]-2-methoxybenzolcarboxamidhydrochlorid |
| o-Anisamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-, monohydrochloride |
| GastreseL.A |
| 4-amino-5-chloro-N-[2-(diéthylamino)éthyl]-2-méthoxybenzamide chlorhydrate |
| Benzamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-2-methoxy-, monohydrochloride |
| Metoclopramide Hydrochloride (500 mg) |
| 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide hydrochloride |
| MFCD00150634 |
| benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, monohydrochloride |
| METOCLOPRAMIDEHYDROCHLORIDE,MONOHYDRATE,USP |
| MetoclopraMide HCI |
| Gastromax |
| 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride |
| metoclopramide monohydrochloride |
| Gastrobidcontinus |
| EINECS 230-634-5 |
| MetoclopraMide Hydrochloride,USP |
| Metoclopramide hydrochloride |
| 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide hydrochloride |
| Metoclopramide (hydrochloride hydrate) |
