CAS 73-05-2|Phentolamine hydrochloride

Introduction：Basic information about CAS 73-05-2|Phentolamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Phentolamine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles37
7. Synonyms

Common Name	Phentolamine hydrochloride
CAS Number	73-05-2	Molecular Weight	317.813
Density	/	Boiling Point	569ºC at 760 mmHg
Molecular Formula	C₁₇H₂₀ClN₃O	Melting Point	>230ºC(dec.)
MSDS	ChineseUSA	Flash Point	297.9ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol,hydrochloride
Synonym	More Synonyms

Phentolamine hydrochloride BiologicalActivity

Description	Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent[1].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Metabolic Disease
References	[1]. P A Majid, et al. Phentolamine for vasodilator treatment of severe heart-failure. Lancet. 1971 Oct 2;2(7727):719-24.

Chemical & Physical Properties

Boiling Point	569ºC at 760 mmHg
Melting Point	>230ºC(dec.)
Molecular Formula	C₁₇H₂₀ClN₃O
Molecular Weight	317.813
Flash Point	297.9ºC
Exact Mass	317.129486
PSA	47.86000
LogP	3.40680
Appearance of Characters	powder \| white to off-white
InChIKey	TUEJFGFQYKDAPM-UHFFFAOYSA-N
SMILES	Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1.Cl
Storage condition	-20°C Freezer
Water Solubility	methanol: 10 mg/mL, clear, colorless

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL0701000

CHEMICAL NAME :: Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphe nyl)amino)-, monohydrochloride

CAS REGISTRY NUMBER :: 73-05-2

LAST UPDATED :: 199009

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H19-N3-O.Cl-H

MOLECULAR WEIGHT :: 317.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	UN 3249
WGK Germany	3
RTECS	SL0701000
Packaging Group	III
Hazard Class	6.1(b)

Articles37

Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.

Br. J. Pharmacol. 171(23) , 5361-75, (2014)

This study examined the role of the main vascular cAMP-hydrolysing phosphodiesterases (cAMP-PDE) in the regulation of basal vascular tone and relaxation of rat aorta mediated by β-adrenoceptors, follo...

Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.

J. Neurosci. 35 , 14070-5, (2015)

Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists ...

Noradrenaline-mediated facilitation of inhibitory synaptic transmission in the dorsal horn of the rat spinal cord involves interlaminar communications.

Eur. J. Neurosci. 42 , 2654-65, (2015)

In the dorsal horn of the spinal cord (DH), noradrenaline (NA) is released by axons originating from the locus coeruleus and induces spinal analgesia, the mechanisms of which are poorly understood. He...

Synonyms

3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)phenol Hydrochloride

2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline Hydrochloride

3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol Hydrochloride

m-(N-(2-Imidazolin-2-ylmethyl)-p-toluidino)phenol monohydrochloride

Fentolamine Hydrochloride

2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Hydrochloride

Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino), monohydrochloride

phentolamin hydrochloride

3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol hydrochloride (1:1)

2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride

EINECS 200-793-5

Phentolamine hydrochloride

Phentolamine HCl

2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline Hydrochloride

Phenol, m-(N-(2-imidazolin-2-ylmethyl)-p-toluidino)-, monohydrochloride (8CI)

Prestwick_386

phentolamine

MFCD00079268

3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol,hydrochloride

50-60-2 (Parent)

3-[N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol,Hydrochlorid

Regitine hydrochloride

Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, hydrochloride (1:1)

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