CAS 145781-92-6|(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt

Introduction：Basic information about CAS 145781-92-6|(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (D-Ser(tBu)6,AzaGly10)-LHRH acetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles10
6. Synonyms

Common Name	(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
CAS Number	145781-92-6	Molecular Weight	1329.46
Density	1.5±0.1 g/cm3	Boiling Point	1695.5ºC at 760mmHg
Molecular Formula	C₆₁H₈₈N₁₈O₁₆	Melting Point	>190°C (dec.)
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS08	Signal Word	Danger

Names

Name	Goserelin Acetate
Synonym	More Synonyms

(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt BiologicalActivity

Description	Goserelin (ICI 118630) acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).IC50 value:Target: GnRH agonistGoserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. It may also be used in the treatment of male-to-female transsexuals and is favoured above other anti-androgens in some countries, such as the UK. It is available as a 1-month depot and a long-acting 3-month depot. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>GNRH ReceptorResearch Areas >>Endocrinology

Description

Goserelin (ICI 118630) acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).IC50 value:Target: GnRH agonistGoserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. It may also be used in the treatment of male-to-female transsexuals and is favoured above other anti-androgens in some countries, such as the UK. It is available as a 1-month depot and a long-acting 3-month depot. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>GNRH ReceptorResearch Areas >>Endocrinology

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	1695.5ºC at 760mmHg
Melting Point	>190°C (dec.)
Molecular Formula	C₆₁H₈₈N₁₈O₁₆
Molecular Weight	1329.46
PSA	493.39000
LogP	-0.95
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.692
InChIKey	IKDXDQDKCZPQSZ-JHYYTBFNSA-N
SMILES	CC(=O)O.CC(C)CC(NC(=O)C(COC(C)(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(N)=O
Storage condition	−20°C
Water Solubility	H2O: 20 mg/mL, clear, colorless

Safety Information

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OK6369800

Articles10

Stability of peptide drugs in the colon.

Eur. J. Pharm. Sci. 78 , 31-6, (2015)

This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclo...

Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo.

Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 1277-83, (2015)

We report potent radiosensitization of prostate cancers in vitro and in vivo using goserelin-conjugated gold nanorods. Progressive receptor-mediated internalization of conjugated nanorods over time in...

Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.

Mol. Pharm. 12(3) , 966-73, (2015)

A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stabil...

Synonyms

Goserelin acetate

Goserelin acetate [D-Ser(tBu)6,Azagly10]-LHRH acetate salt

Goserelin (acetate)

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