Introduction：Basic information about CAS 99464-64-9|ampiroxicam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ampiroxicam |
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| CAS Number | 99464-64-9 | Molecular Weight | 447.462 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C20H21N3O7S | Melting Point | 159-161?C |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | ampiroxicam |
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| Synonym | More Synonyms |
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ampiroxicam BiologicalActivity
| Description | Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.Target: COXAmpiroxicam is a non-steroidal anti-inflammatory drug. It is a prodrug of piroxicam. Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats [1]. Ultraviolet-A (UVA)-irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS). Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam [2]. |
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| Related Catalog | Natural Products >>AlkaloidResearch Areas >>Inflammation/Immunology |
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| Target | COX |
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| References | [1]. Aoki T, et al. Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery. Int J Oral Maxillofac Surg. 2006 Jul;35(7):613-7. [2]. Sasaki, T., et al., Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity. J Dermatol Sci, 1999. 21(3): p. 170-5. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Melting Point | 159-161?C |
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| Molecular Formula | C20H21N3O7S |
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| Molecular Weight | 447.462 |
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| Exact Mass | 447.110016 |
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| PSA | 132.51000 |
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| LogP | 3.12 |
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| Index of Refraction | 1.630 |
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| InChIKey | LSNWBKACGXCGAJ-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21 |
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| Storage condition | -20°C Freezer |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Precautionary Statements | P301 + P312 + P330 |
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| RIDADR | NONH for all modes of transport |
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| RTECS | FG1602400 |
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| HS Code | 2942000000 |
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Customs
Synonyms
| (±)-4-(1-Hydroxyethoxy)-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide ethyl carbonate (ester) 1,1-dioxide |
| Ethyl 1-{[2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2H-1,2-benzothiazin-4-yl]oxy}ethyl carbonate |
| ampiroxicam |
| 4-{1-[(Ethoxycarbonyl)oxy]ethoxy}-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide S,S-dioxide |
| Ethyl 1-{[2-methyl-1,1-dioxido-3-(2-pyridinylcarbamoyl)-2H-1,2-benzothiazin-4-yl]oxy}ethyl carbonate |
| 4-[1-(Ethoxycarbonyloxy)ethoxy]-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide |
| Ampiroxicamum [Latin] |
| MFCD00866079 |
| 4-[1-(Ethoxycarbonyloxy)ethoxy]-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide |
| Flucam |
| Carbonic acid, ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester |
| ethyl 1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ<sup>6</sup>,2-benzothiazin-4-yl]oxy]ethyl carbonate |
| Ampiroxicamum |
