Introduction：Basic information about CAS 59338-93-1|Alizapride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alizapride |
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| CAS Number | 59338-93-1 | Molecular Weight | 315.37000 |
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| Density | 1.224 g/cm3 | Boiling Point | 597.6ºC at 760 mmHg |
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| Molecular Formula | C16H21N5O2 | Melting Point | 3360°C |
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| MSDS | / | Flash Point | 315.2ºC |
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Names
| Name | N-((1-Allylpyrrolidin-2-yl)methyl)-6-methoxy-1H-benzo[d][1,2,3]triazole-5-carboxamide |
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| Synonym | More Synonyms |
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Alizapride BiologicalActivity
| Description | Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | Dopamine 2 receptor |
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| In Vivo | Alizapride (2.5, 5, 10, 25 μg/kg; SC; 7 consecutive days) significantly reduces the bound IgG-sensitized erythrocytes with Splenic macrophages isolated from animals[2]. Animal Model: Male Duncan–Hartley guinea pigs[2] Dosage: 2.5, 5, 10, 25 μg/kg Administration: Alizapride (2.5, 5, 10, 25 μg/kg; SC; 7 consecutive days) Result: Reduced the clearance of IgG-sensitized RBCs. |
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| References | [1]. P L Warzee, et al. Manometric study of the activity of alizapride on the motor function of the human sphincter of Oddi. J Clin Pharm Ther. 1988 Aug;13(4):281-4. [2]. Gomez, et al. Macrophage Fcgamma receptors expression is altered by treatment with dopaminergic drugs. Clinical immunology (Orlando, Fla.) vol. 90,3 (1999): 375-87. [3]. Seng, et al. Anti-emetic effect of high-dose metoclopramide vs alizapride--a randomised crossover study. British journal of clinical pharmacology vol. 38,3 (1994): 282-4. |
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Chemical & Physical Properties
| Density | 1.224 g/cm3 |
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| Boiling Point | 597.6ºC at 760 mmHg |
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| Melting Point | 3360°C |
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| Molecular Formula | C16H21N5O2 |
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| Molecular Weight | 315.37000 |
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| Flash Point | 315.2ºC |
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| Exact Mass | 315.17000 |
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| PSA | 83.14000 |
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| LogP | 1.67550 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DM1250000
- CHEMICAL NAME :
- 1H-Benzotriazole-5-carboxamide, 6-methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-
- CAS REGISTRY NUMBER :
- 59338-93-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H21-N5-O2
- MOLECULAR WEIGHT :
- 315.42
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 14 mg/kg/10H-I
- TOXIC EFFECTS :
- Behavioral - headache Vascular - BP elevation not characterized in autonomic section
- REFERENCE :
- NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 312,1125,1985
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Safety Information
| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide |
| EINECS 261-710-6 |
| MFCD00867757 |
