CAS 51529-01-2|cis-(Z)-Flupentixol dihydrochloride
| Common Name | cis-(Z)-Flupentixol dihydrochloride | ||
|---|---|---|---|
| CAS Number | 51529-01-2 | Molecular Weight | 507.440 |
| Density | / | Boiling Point | 554.7ºC at 760 mmHg |
| Molecular Formula | C23H27Cl2F3N2OS | Melting Point | 194-202ºC |
| MSDS | ChineseUSA | Flash Point | 289.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Flupenthixol dihydrochloride |
|---|---|
| Synonym | More Synonyms |
cis-(Z)-Flupentixol dihydrochloride BiologicalActivity
| Description | cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| Target | D2 Receptor:0.38 nM (Ki) 5-HT2A Receptor:7 nM (Ki) |
| In Vivo | cis-(Z)-Flupentixol (0.25, or 0.5 mg/kg, i.p.) pretreatment dose-dependently reduces cocaine-induced activity[1]. Animal Model: Rats[1]. Dosage: 0.125, 0.25, or 0.5 mg/kg. Administration: IP. Result: Reduced cocaine-induced activity. |
| References | [1]. Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6. [2]. Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. |
Chemical & Physical Properties
| Boiling Point | 554.7ºC at 760 mmHg |
|---|---|
| Melting Point | 194-202ºC |
| Molecular Formula | C23H27Cl2F3N2OS |
| Molecular Weight | 507.440 |
| Flash Point | 289.3ºC |
| Exact Mass | 506.117310 |
| PSA | 52.01000 |
| LogP | 6.08150 |
| Appearance of Characters | white to off-white |
| InChIKey | ZQAWQVWCKYGMNE-CVIBNLPVSA-N |
| SMILES | Cl.OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 |
| Storage condition | -20°C Freezer |
| Water Solubility | H2O: soluble |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 |
| Precautionary Statements | P261-P280-P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S36/37/39 |
| RIDADR | UN 2811 |
| RTECS | TL9900000 |
| HS Code | 2942000000 |
Customs
| HS Code | 2942000000 |
|---|
Articles7
More Articles| Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors. PLoS Negl. Trop. Dis. 9(3) , e0003515, (2015) New mode-of-action insecticides are sought to provide continued control of pesticide resistant arthropod vectors of neglected tropical diseases (NTDs). We previously identified antagonists of the AaDO... | |
| The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection. Behav. Pharmacol. 26(1-2) , 193-9, (2014) The reinforcing and addictive properties of cocaine are thought to rely on the dopaminergic innervation of the striatum. The ventromedial [i.e. nucleus accumbens shell (NAcc) shell] and dorsolateral [... | |
| A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity. Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing... |
Synonyms
| 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-, dihydrochloride (8CI) |
| (Z)-4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol dihydrochloride |
| 1-Piperazineethanol, 4-[3-[2- (trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, dihydrochloride |
| cis-Flupentixol Hydrochloride |
| FUPENTIXOL DIHYDROCHLORIDE |
| FLUPENTIXOL DIHYDROCHLORIDE |
| 4-[3-[(3Z)-2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Hydrochloride |
| a-Flupenthixol Hydrochloride |
| Zimelidine dihydrochloride |
| Fupentixol HCl |
| 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride |
| (Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride |
| 2-(4-{(3E)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}-1-piperazinyl)ethanol dihydrochloride |
| 2-(4-{(3E)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol dihydrochloride |
| Metamin |
| 1-Piperazineethanol, 4-[(3E)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, hydrochloride (1:2) |
| Thioxanthene, 9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-trifluoromethyl-, dihydrochloride |
| Fluanxol dihydrochloride |
| 1-Piperazineethanol, 4-[(3Z)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, hydrochloride (1:2) |
| 2-(4-{(3Z)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}-1-piperazinyl)ethanol dihydrochloride |
| 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-, dihydrochloride (9CI) |
| CIS-(Z)-FLUPENTHIXOL DIHYDROCHLORIDE ANT IPSYCHOTIC,NEUROL |
| 1-Piperazineethanol, 4-[3-[2- (trifluoromethyl)thioxanthen-9-ylidene]propyl]-, dihydrochloride |
| 2-(4-{(3Z)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol dihydrochloride |
| flupentixolhydrochloride |
| fx703 |
| cis-(Z)-Flupentixol Dihydrochloride |
