Introduction：Basic information about CAS 1197-09-7|1-(3,4-Dihydroxyphenyl)ethanone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-(3,4-Dihydroxyphenyl)ethanone |
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| CAS Number | 1197-09-7 | Molecular Weight | 152.147 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 372.4±27.0 °C at 760 mmHg |
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| Molecular Formula | C8H8O3 | Melting Point | 117 °C |
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| MSDS | / | Flash Point | 193.2±20.2 °C |
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Names
| Name | 3',4'-dihydroxyacetophenone |
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| Synonym | More Synonyms |
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1-(3,4-Dihydroxyphenyl)ethanone BiologicalActivity
| Description | 3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC50 of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Tyrosinase |
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| Target | IC50: 10 μM (Tyrosinase)[1]. |
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| References | [1]. You Jung Kim, et al. Antimelanogenic Activity of 3,4-dihydroxyacetophenone: Inhibition of Tyrosinase and MITF. Biosci Biotechnol Biochem. 2006 Feb;70(2):532-4. [2]. Xiao Ruan, et al. Autotoxicity and Allelopathy of 3,4-dihydroxyacetophenone Isolated From Picea Schrenkiana Needles. Molecules. 2011 Oct 24;16(10):8874-93. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 372.4±27.0 °C at 760 mmHg |
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| Melting Point | 117 °C |
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| Molecular Formula | C8H8O3 |
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| Molecular Weight | 152.147 |
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| Flash Point | 193.2±20.2 °C |
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| Exact Mass | 152.047348 |
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| PSA | 57.53000 |
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| LogP | 1.28 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.595 |
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| InChIKey | UCQUAMAQHHEXGD-UHFFFAOYSA-N |
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| SMILES | CC(=O)c1ccc(O)c(O)c1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- KM5775200
- CHEMICAL NAME :
- Ethanone, 1-(3,4-dihydroxyphenyl)-
- CAS REGISTRY NUMBER :
- 1197-09-7
- LAST UPDATED :
- 199503
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C8-H8-O3
- MOLECULAR WEIGHT :
- 152.16
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 235 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 11,358,1980
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| RTECS | KM5775200 |
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| HS Code | 2914501900 |
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Customs
| HS Code | 2914501900 |
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| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 3,4-Dihydroxyacetophenone |
| 4-Acetocatechol |
| 4-Acetylpyrocatechol |
| 3',4'-Dihydroxyacetophenone |
| MFCD00016439 |
| 1-(3,4-Dihydroxyphenyl)ethanone |
| Ethanone, 1-(3,4-dihydroxyphenyl)- |
