CAS 142-91-6|Isopropyl palmitate
Introduction：Basic information about CAS 142-91-6|Isopropyl palmitate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Isopropyl palmitate | ||
|---|---|---|---|
| CAS Number | 142-91-6 | Molecular Weight | 298.51 |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 340.7±10.0 °C at 760 mmHg |
| Molecular Formula | C19H38O2 | Melting Point | 11-13 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 162.2±8.8 °C |
Names
| Name | isopropyl palmitate |
|---|---|
| Synonym | More Synonyms |
Isopropyl palmitate BiologicalActivity
| Description | Isopropyl palmitate is an fatty acid ester. Isopropyl palmitate can be used for design and characterization of bioactive bilayer films. The bilayer membrane not only has the ability to scavenge free radicals and inhibit lipid peroxidation, but also can inhibit the growth of known foodborne pathogens. Isopropyl palmitate can be used as an excipient, such as lubricant, oily carrier, solvent, controlled-release transdermal film. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Others |
| References | [1]. Luís Â, et al. Design and Characterization of Bioactive Bilayer Films: Release Kinetics of Isopropyl Palmitate. Antibiotics (Basel). 2020 Jul 24;9(8):443. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. |
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 340.7±10.0 °C at 760 mmHg |
| Melting Point | 11-13 °C(lit.) |
| Molecular Formula | C19H38O2 |
| Molecular Weight | 298.51 |
| Flash Point | 162.2±8.8 °C |
| Exact Mass | 298.287170 |
| PSA | 26.30000 |
| LogP | 8.49 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.443 |
| InChIKey | XUGNVMKQXJXZCD-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCC(=O)OC(C)C |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- REFERENCE :
- 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,727,1982 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,727,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,727,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82948 No. of Facilities: 1596 (estimated) No. of Industries: 18 No. of Occupations: 43 No. of Employees: 75810 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82948 No. of Facilities: 2360 (estimated) No. of Industries: 18 No. of Occupations: 48 No. of Employees: 200948 (estimated) No. of Female Employees: 162709 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
|---|---|
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | - |
| RTECS | RT4900000 |
| HS Code | 2915709000 |
Customs
| HS Code | 2915709000 |
|---|---|
| Summary | 2915709000. palmitic acid and its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
Articles27
More Articles| Transdermal delivery of curcumin via microemulsion. Int. J. Pharm. 481(1-2) , 97-103, (2015) The objective of this study was to evaluate the transdermal delivery potential of a new curcumin-containing microemulsion system. Three series of experiments were carried out to comprehend the system ... | |
| Comparative percutaneous permeation study using caffeine-loaded microemulsion showing low reliability of the frozen/thawed skin models. Int. J. Pharm. 471(1-2) , 516-24, (2014) The aim of this study was to explore the transdermal delivery potential of a new caffeine-containing microemulsion system. The skin permeability of caffeine (CAF) was measured in vitro using skin exci... | |
| Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity. Int. J. Pharm. 487 , 148-56, (2015) The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as mel... |
Synonyms
| Hexadecanoic acid 1-methylethyl ester |
| Isopropyl hexadecanoate |
| Hexadecanoic acid, 1-methylethyl ester |
| Isopropyl palmitate |
| Palmitic Acid Isopropyl Ester |
| propan-2-yl hexadecanoate |
| MFCD00008993 |
| EINECS 205-571-1 |
