CAS 124937-52-6|Tolterodine tartrate

Introduction：Basic information about CAS 124937-52-6|Tolterodine tartrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tolterodine tartrate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Tolterodine tartrate
CAS Number	124937-52-6	Molecular Weight	475.574
Density	1.003 g/cm3	Boiling Point	442.2ºC at 760 mmHg
Molecular Formula	C₂₆H₃₇NO₇	Melting Point	205-210ºC
MSDS	ChineseUSA	Flash Point	192.1ºC
Symbol	GHS06, GHS08	Signal Word	Danger

Names

Name	tolterodine tartrate
Synonym	More Synonyms

Tolterodine tartrate BiologicalActivity

Description	Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value:Target: mAChRin vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1].in vivo: Tolterodine was extensively metabolized in vivo [2]. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased [3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Neurological Disease
References	[1]. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7. [2]. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35. [3]. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.

Description

Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value:Target: mAChRin vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1].in vivo: Tolterodine was extensively metabolized in vivo [2]. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased [3].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Neurological Disease

References

[1]. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7.

[2]. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35.

[3]. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.

Chemical & Physical Properties

Density	1.003 g/cm3
Boiling Point	442.2ºC at 760 mmHg
Melting Point	205-210ºC
Molecular Formula	C₂₆H₃₇NO₇
Molecular Weight	475.574
Flash Point	192.1ºC
Exact Mass	475.256989
PSA	138.53000
LogP	3.21880
Vapour Pressure	1.97E-08mmHg at 25°C
InChIKey	TWHNMSJGYKMTRB-KXYUELECSA-N
SMILES	Cc1ccc(O)c(C(CCN(C(C)C)C(C)C)c2ccccc2)c1.O=C(O)C(O)C(O)C(=O)O
Storage condition	Store at +4°C

Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H361
Precautionary Statements	Missing Phrase - N15.00950417-P280
Hazard Codes	Xi: Irritant;
Risk Phrases	R20/21/22
Safety Phrases	S36/37
RIDADR	NONH for all modes of transport
HS Code	2922299090

Customs

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

(R)-2-(3-(DIISOPROPYLAMINO)-1-PHENYLPROPYL)-4-METHYLPHENOL 2,3-DIHYDROXYSUCCINATE

(R)-2-(3-DIISOPROPYLAMINO-1-PHENYL-PROPYL)-4-METHYL-PHENOL L-TARTRATE

2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-methylphenol 2,3-dihydroxybutanedioate (1:1)

MFCD07771985

(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol (2R,3R)-2,3-dihydroxysuccinate

(+/-)-TOLTERODINE-D14 TARTRATE

TOLTERODINE

(+)-R)-2-{ALPHA-[2-(DIISOPROPYLAMINO)ETHYL]BENZYL}-P-CRESOL TARTRATE

(+)-R)-2-{A-[2-(DIISOPROPYLAMINO)ETHYL]BENZYL}-P-CRESOL TARTRATE

RIFABUTENE

Tolterodine L-Tartrate

TOLERODINE TARTRATE

Tolterodine tartrate

Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol (1:1)

TOLTERODINE TARTRATE, CERTIFIED REFERENCE MATERIAL

(2R,3R)-2,3-Dihydroxysuccinic acid - 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol (1:1)

(R)-2-(3-Diisopropylamino-1-phenyl-propyl)-p-cresol L-tartrate

Tolterodine (Tartrate)

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