CAS 110-85-0|Piperazine

Introduction：Basic information about CAS 110-85-0|Piperazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Piperazine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles51
8. Synonyms

Common Name	Piperazine
CAS Number	110-85-0	Molecular Weight	86.136
Density	0.9±0.1 g/cm3	Boiling Point	149.3±8.0 °C at 760 mmHg
Molecular Formula	C₄H₁₀N₂	Melting Point	109-112 °C(lit.)
MSDS	ChineseUSA	Flash Point	49.7±10.2 °C
Symbol	GHS05, GHS08	Signal Word	Danger

Names

Name	piperazine
Synonym	More Synonyms

Piperazine BiologicalActivity

Description	Piperazine is an anthelmintic.
Related Catalog	Research Areas >>Others
In Vitro	Piperazine (0.01-0.1 mM) slightly inhibits nematodes development compared to control. Piperazine (1 μM) reduces the total brood size of the nematodes. Piperazine increases the the percentage of zebrafish with developmental delay in a dose-dependent manner[1]. Piperazine is attractive solvent for CO2 capture, and the facile Piperazine liberation may contribute to its relatively high CO2 absorption rate[2].
References	[1]. Racz PI, et al. Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds. Toxicol In Vitro. 2017 Oct;44:11-16. [2]. Stowe HM, et al. First-principles assessment of CO2 capture mechanisms in aqueous piperazine solution. Phys Chem Chem Phys. 2016 Sep 14;18(36):25296-25307.

Chemical & Physical Properties

Density	0.9±0.1 g/cm3
Boiling Point	149.3±8.0 °C at 760 mmHg
Melting Point	109-112 °C(lit.)
Molecular Formula	C₄H₁₀N₂
Molecular Weight	86.136
Flash Point	49.7±10.2 °C
Exact Mass	86.084396
PSA	24.06000
LogP	-1.17
Vapour Pressure	4.0±0.3 mmHg at 25°C
Index of Refraction	1.424
InChIKey	GLUUGHFHXGJENI-UHFFFAOYSA-N
SMILES	C1CNCCN1
Stability	Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
Water Solubility	150 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK7800000

CHEMICAL NAME :: Piperazine

CAS REGISTRY NUMBER :: 110-85-0

BEILSTEIN REFERENCE NO. :: 0102555

LAST UPDATED :: 199704

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C4-H10-N2

MOLECULAR WEIGHT :: 86.16

WISWESSER LINE NOTATION :: T6M DMTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1967

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,862,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Gastrointestinal - nausea or vomiting

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,478,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,414,1964

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5400 mg/m3/2H

TOXIC EFFECTS :: Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year: 1,542,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1965 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND:TWA 1 mg/m3;STEL 5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.3 mg/m3);STEL 0.3 ppm (1 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84705 No. of Facilities: 132 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 2512 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84705 No. of Facilities: 435 (estimated) No. of Industries: 10 No. of Occupations: 25 No. of Employees: 8786 (estimated) No. of Female Employees: 2609 (estimated)

Safety Information

Symbol	GHS05, GHS08
Signal Word	Danger
Hazard Statements	H314-H317-H334-H361fd
Precautionary Statements	P261-P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive
Risk Phrases	R34;R42/43;R52/53
Safety Phrases	S22-S26-S36/37/39-S45-S61
RIDADR	UN 2579 8/PG 3
WGK Germany	1
RTECS	TK7800000
Packaging Group	III
Hazard Class	8
HS Code	2933599090

Customs

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles51

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Mutations in intron 1 and intron 22 inversion negative haemophilia A patients from Western India.

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Synonyms

PIPERAZINE CHIPS

Hexahydropyrazine

Pyrazine hexahydride

Trimetazidine Hydrochloride Impurity G

1,4-diazacyclohexane

1,4-piperazine

Diethylenediamine

Piperazine

1,4-Diazacyclohexan

EINECS 203-808-3

MFCD00005953

1,4-DIAZACYCLOHEXANE, CERTIFIED REFERENCE MATERIAL

1,4-Diazacyclohexane,Diethylenediamine

Trimetazidine Impurity G

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