Introduction：Basic information about CAS 124168-73-6|4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt |
|---|
| CAS Number | 124168-73-6 | Molecular Weight | 490.553 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C23H34N6O6 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | / |
|---|
Names
| Name | 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid |
|---|
| Synonym | More Synonyms |
|---|
BiologicalActivity
| Description | FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2]. |
|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>MMP |
|---|
| In Vitro | FN-439 inhibits collagenase-1 with an IC50 value of 1 μM[1]. FN-439 (1 μM) reduces the invasive potential of MDA-MB-231 breast cancer cells[1]. |
|---|
| In Vivo | FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci[2]. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Molecular Formula | C23H34N6O6 |
|---|
| Molecular Weight | 490.553 |
|---|
| Exact Mass | 490.253998 |
|---|
| PSA | 182.96000 |
|---|
| LogP | -0.69 |
|---|
| Index of Refraction | 1.583 |
|---|
| InChIKey | WWHUHFFMOPIVKB-OLMNPRSZSA-N |
|---|
| SMILES | CC(C)CC(NC(=O)C1CCCN1C(=O)CNC(=O)c1ccc(N)cc1)C(=O)NC(C)C(=O)NO |
|---|
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|
| RIDADR | NONH for all modes of transport |
|---|
Articles7
More Articles
| Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons. Int. J. Mol. Sci. 16 , 15659-69, (2015) Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal ... | |
| Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids. Biochem. Biophys. Res. Commun. 199 , 1442-6, (1994) Synthetic inhibitors of interstitial collagenase, tri- and tetrapeptidyl hydroxamic acids, have been developed and tested for their inhibitory activities against human matrix metalloproteinases. A wat... | |
| Vertebrate collagenase inhibitor. II. Tetrapeptidyl hydroxamic acids. Chem. Pharm. Bull. Tokyo 39 , 1489-1494, (1991) To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38... | |
Synonyms
| D-Alaninamide, N-(4-aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy- |
| 1-[2-[(4-aminobenzoyl)amino]acetyl]-N-[1-[[1-(hydroxyamino)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide |
| MFCD00237459 |
| N-(4-Aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-D-alaninamide |
