CAS 382180-17-8|N-Hydroxy-N'-(3-pyridinyl)octanediamide
Introduction：Basic information about CAS 382180-17-8|N-Hydroxy-N'-(3-pyridinyl)octanediamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-Hydroxy-N'-(3-pyridinyl)octanediamide | ||
|---|---|---|---|
| CAS Number | 382180-17-8 | Molecular Weight | 265.308 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C13H19N3O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N'-hydroxy-N-pyridin-3-yloctanediamide |
|---|---|
| Synonym | More Synonyms |
N-Hydroxy-N'-(3-pyridinyl)octanediamide BiologicalActivity
| Description | Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>HDACSignaling Pathways >>Epigenetics >>HDAC |
| Target | ID50: 100 nM[1] |
| In Vitro | Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture[1]. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively[1]. Cell Viability Assay[2] Cell Line: RD cells; RH30B cells Concentration: 1.25-20.0 μM Incubation Time: 24 hours; 48 hours; 72 hours Result: Resulted in a cell growth decrease in RD and RH30B cells. Cell Cycle Analysis[2] Cell Line: RD cells; RH30B cells Concentration: 10.0 μM; 20.0 μM Incubation Time: 48 hours Result: Increased the sub-G1 fractions at 48 hours compared with control samples. |
| References | [1]. Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7(4):962-70. [2]. Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15;9(15):5749-55. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C13H19N3O3 |
| Molecular Weight | 265.308 |
| Exact Mass | 265.142639 |
| PSA | 91.32000 |
| LogP | 0.04 |
| Appearance of Characters | white to beige |
| Index of Refraction | 1.570 |
| InChIKey | PTJGLFIIZFVFJV-UHFFFAOYSA-N |
| SMILES | O=C(CCCCCCC(=O)Nc1cccnc1)NO |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble10mg/mL (clear solution) |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles1
More Articles| Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorg. Med. Chem. 23 , 5151-5, (2015) Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDAC... |
Synonyms
| S2190_Selleck |
| N-Hydroxy-N'-3-pyridinyloctanediamide |
| N-Hydroxy-N'-(pyridin-3-yl)octanediamide |
| N1-Hydroxy-N8-3-pyridinyl-octanediamide |
| Octanediamide, N-hydroxy-N-3-pyridinyl- |
| N-Hydroxy-N'-(3-pyridinyl)octanediamide |
| pyroxamide |
| N-Hydroxy-N'-3-pyridinyl octane diamide |
