Introduction：Basic information about CAS 14663-53-7|(4-Oxo-4H-quinazolin-3-yl)-acetic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (4-Oxo-4H-quinazolin-3-yl)-acetic acid |
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| CAS Number | 14663-53-7 | Molecular Weight | 204.18200 |
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| Density | / | Boiling Point | 444.6ºC at 760mmHg |
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| Molecular Formula | C10H8N2O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-(4-oxoquinazolin-3-yl)acetic acid |
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| Synonym | More Synonyms |
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(4-Oxo-4H-quinazolin-3-yl)-acetic acid BiologicalActivity
| Description | (4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Alkyl-Chain |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Boiling Point | 444.6ºC at 760mmHg |
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| Molecular Formula | C10H8N2O3 |
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| Molecular Weight | 204.18200 |
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| Exact Mass | 204.05300 |
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| PSA | 72.19000 |
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| LogP | 0.48110 |
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| Vapour Pressure | 1.1E-08mmHg at 25°C |
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| Index of Refraction | 1.659 |
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| InChIKey | BBBICQPTZBHLBM-UHFFFAOYSA-N |
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| SMILES | O=C(O)Cn1cnc2ccccc2c1=O |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-Oxo-3,4-dihydro-chinazolyl-3-essigsaeure |
| 2-(4-oxo-3-hydroquinazolin-3-yl)acetic acid |
| (4-Oxo-4H-quinazolin-3-yl)-acetic acid |
| (4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid |
| (4-Oxo-4H-chinazolin-3-yl)-essigsaeure |
| 3-carboxymethyl-3,4-dihydro-4(1H)-quinazolinone |
| (4-oxoquinazolin-3(4H)-yl)acetic acid |
| N-carboxymethyl-4(3H)-quinazolinone |
| 2-(4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid |
| 2-(4-Oxoquinazolin-3(4H)-yl)acetic acid |
| 3(4h)-quinazolineacetic acid,4-oxo |
| (4-oxo-3,4-dihydroquinazolin-3-yl)acetate |
