CAS 86215-36-3|1-(3,4-DICHLOROBENZYL)PIPERAZINE
Introduction：Basic information about CAS 86215-36-3|1-(3,4-DICHLOROBENZYL)PIPERAZINE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-(3,4-DICHLOROBENZYL)PIPERAZINE | ||
|---|---|---|---|
| CAS Number | 86215-36-3 | Molecular Weight | 264.58 |
| Density | / | Boiling Point | 324.4ºC at 760 mmHg |
| Molecular Formula | C11H12Cl3N | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 150ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,hydrochloride |
|---|---|
| Synonym | More Synonyms |
1-(3,4-DICHLOROBENZYL)PIPERAZINE BiologicalActivity
| Description | DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Dopamine TransporterResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>Serotonin Transporter |
| Target | 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT[2] |
| References | [1]. Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. [2]. Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. [3]. Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. |
Chemical & Physical Properties
| Boiling Point | 324.4ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H12Cl3N |
| Molecular Weight | 264.58 |
| Flash Point | 150ºC |
| Exact Mass | 263.00400 |
| PSA | 12.03000 |
| LogP | 3.98510 |
| InChIKey | KAGBHVBIOJBGBD-UHFFFAOYSA-N |
| SMILES | Cl.Clc1ccc(C23CNCC2C3)cc1Cl |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319 |
| Precautionary Statements | P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 2811 6.1 / PGIII |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| dov 216,303 hydrochloride |
