CAS 84378-44-9|Flumazenil acid

Introduction：Basic information about CAS 84378-44-9|Flumazenil acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Flumazenil acid BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Flumazenil acid
CAS Number	84378-44-9	Molecular Weight	275.24
Density	1.6±0.1 g/cm3	Boiling Point	570.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₀FN₃O₃	Melting Point	/
MSDS	/	Flash Point	298.8±30.1 °C

Names

Name	8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
Synonym	More Synonyms

Flumazenil acid BiologicalActivity

Description	Flumazenil acid is a metabolite of Flumazenil[1]. Flumazenil is a GABAA receptor antagonist[2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor
References	[1]. Kleingeist B, et al. Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase. J Pharm Pharm Sci. 1998 Jan-Apr;1(1):38-46. [2]. Mograbi KM, et al. Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice. Physiol Rep. 2017 Mar;5(6). pii: e13081.

Description

Flumazenil acid is a metabolite of Flumazenil[1]. Flumazenil is a GABAA receptor antagonist[2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor

References

[1]. Kleingeist B, et al. Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase. J Pharm Pharm Sci. 1998 Jan-Apr;1(1):38-46.

[2]. Mograbi KM, et al. Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice. Physiol Rep. 2017 Mar;5(6). pii: e13081.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	570.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₀FN₃O₃
Molecular Weight	275.24
Flash Point	298.8±30.1 °C
Exact Mass	275.070618
PSA	75.43000
LogP	-0.16
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.697
InChIKey	SFVXVWJBSJCRJO-UHFFFAOYSA-N
SMILES	CN1Cc2c(C(=O)O)ncn2-c2ccc(F)cc2C1=O

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

Flumazenil acid

3-desmethylflumazenil

4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-

8-Fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

desethylflumazenyl

desethylflumazenil

Ro 15-3890

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