Introduction：Basic information about CAS 4201-22-3|Tolonidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tolonidine |
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| CAS Number | 4201-22-3 | Molecular Weight | 209.67500 |
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| Density | 1.31g/cm3 | Boiling Point | 314ºC at 760 mmHg |
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| Molecular Formula | C10H12ClN3 | Melting Point | / |
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| MSDS | / | Flash Point | 143.7ºC |
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Names
| Name | N-(2-chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine |
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| Synonym | More Synonyms |
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Tolonidine BiologicalActivity
| Description | Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| In Vivo | In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances[1]. In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties[1]. |
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| References | [1]. Cosnier D, et al. Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis. Arzneimittelforschung. 1975 Nov;25(11):1802-6. |
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Chemical & Physical Properties
| Density | 1.31g/cm3 |
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| Boiling Point | 314ºC at 760 mmHg |
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| Molecular Formula | C10H12ClN3 |
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| Molecular Weight | 209.67500 |
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| Flash Point | 143.7ºC |
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| Exact Mass | 209.07200 |
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| PSA | 36.42000 |
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| LogP | 1.85690 |
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| Index of Refraction | 1.637 |
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| InChIKey | KWBTZIFLQYYPTH-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(NC2=NCCN2)c(Cl)c1 |
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Safety Information
Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Tolonidina |
| Tolonidinum |
| ST-375 |
| Tolonidine |
| Euctan |
