CAS 140-40-9|Nithiamide
Introduction：Basic information about CAS 140-40-9|Nithiamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nithiamide | ||
|---|---|---|---|
| CAS Number | 140-40-9 | Molecular Weight | 187.17600 |
| Density | 1.598g/cm3 | Boiling Point | 303.8ºC at 760mmHg |
| Molecular Formula | C5H5N3O3S | Melting Point | 263°C (dec.) |
| MSDS | ChineseUSA | Flash Point | 137.5ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-Acetamido-5-nitrothiazole |
|---|---|
| Synonym | More Synonyms |
Nithiamide BiologicalActivity
| Description | Nithiamide is a non-5-nitroimidazole drugs, is a antibiotic used in veterinary. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
Chemical & Physical Properties
| Density | 1.598g/cm3 |
|---|---|
| Boiling Point | 303.8ºC at 760mmHg |
| Melting Point | 263°C (dec.) |
| Molecular Formula | C5H5N3O3S |
| Molecular Weight | 187.17600 |
| Flash Point | 137.5ºC |
| Exact Mass | 187.00500 |
| PSA | 116.05000 |
| LogP | 1.60590 |
| Vapour Pressure | 0.000911mmHg at 25°C |
| Index of Refraction | 1.666 |
| InChIKey | UJRRDDHEMZLWFI-UHFFFAOYSA-N |
| SMILES | CC(=O)Nc1ncc([N+](=O)[O-])s1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Blood - changes in cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - turkey
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 200 ppm
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,153,1983
- TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 200 ppm
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,153,1983
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S22-S36/37 |
| RIDADR | NONH for all modes of transport |
| RTECS | XJ1570000 |
| HS Code | 2934100090 |
Customs
| HS Code | 2934100090 |
|---|---|
| Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
Articles11
More Articles| Back to the future: oral targeted therapy for RA and other autoimmune diseases. Nat. Rev. Rheumatol. 9(3) , 173-82, (2013) The molecular biology revolution coupled with the development of monoclonal antibody technology enabled remarkable progress in rheumatology therapy, comprising an array of highly effective biologic ag... | |
| [The treatment of intra-abdominal abscess]. Klin. Khir. (7) , 32-3, (1998) The experience of treatment of 18 patients with intraabdominal abscess using the regional laparostomy conduction and introducing nitazol, immobilized on polymethylsiloxane, in the abscess cavity, was ... | |
| [Nitazole--an antimicrobial substance]. Mikrobiol. Z. 60(1) , 83-91, (1998) The antibacterial activity of protistocide drug nitazole has been revealed for the first time in the 80's at the Laboratory of Clinical Microbiology of the Mechnikov Research Institute of Microbiology... |
Synonyms
| EINECS 205-414-7 |
| MFCD00022438 |
| N-(5-nitro-1,3-thiazol-2-yl)acetamide |
| 2-Acetamido-5-Nitrothiazole |
| N-(5-Nitrothiazol-2-yl)acetamide |
| Nithiamide |
