Introduction：Basic information about CAS 4055-39-4|Mitomycin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mitomycin A |
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| CAS Number | 4055-39-4 | Molecular Weight | 349.34 |
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| Density | 1.5g/cm3 | Boiling Point | 587.4ºC at 760 mmHg |
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| Molecular Formula | C16H19N3O6 | Melting Point | 159-161ºC (dec) |
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| MSDS | / | Flash Point | 309.1ºC |
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Names
| Name | mitomycin A |
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| Synonym | More Synonyms |
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Mitomycin A BiologicalActivity
| Description | Mitomycin A is a bacterial metabolite. Mitomycin A reduces migration inhibition factor (MIF) production and can be used for the research of cancer[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| References | [1]. van der Nat JM, et al. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro. Immunobiology. 1986 Aug;172(1-2):120-7. |
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Chemical & Physical Properties
| Density | 1.5g/cm3 |
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| Boiling Point | 587.4ºC at 760 mmHg |
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| Melting Point | 159-161ºC (dec) |
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| Molecular Formula | C16H19N3O6 |
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| Molecular Weight | 349.34 |
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| Flash Point | 309.1ºC |
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| Exact Mass | 349.12700 |
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| PSA | 130.10000 |
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| LogP | 0.00350 |
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| Vapour Pressure | 8.83E-14mmHg at 25°C |
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| Index of Refraction | 1.638 |
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| InChIKey | HYFMSAFINFJTFH-NGSRAFSJSA-N |
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| SMILES | COC1=C(C)C(=O)C2=C(C1=O)C(COC(N)=O)C1(OC)C3NC3CN21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CN1050000
- CAS REGISTRY NUMBER :
- 4055-39-4
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C16-H19-N3-O6
- MOLECULAR WEIGHT :
- 349.38
- WISWESSER LINE NOTATION :
- T D3 B556 BN EM JV MVTTT&J GO1 H1OVZ KO1 L1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 3 ug/L
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,767,1977
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Synonyms
| [(1aS,8S,8aR,8bS)-6,8a-Dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2,3,4]pyrrolo[1,2-a]indol-8-yl]methyl Carbamate |
| mitomycin-A |
| Mitomycin A |
| (1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione |
