Introduction：Basic information about CAS 35286-58-9|Kudinoside H, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kudinoside H |
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| CAS Number | 35286-58-9 | Molecular Weight | 766.955 |
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| Density | 1.35 | Boiling Point | 841.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C41H66O13 | Melting Point | 198-202ºC |
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| MSDS | / | Flash Point | 247.2±27.8 °C |
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Names
| Name | Ziyuglycoside I |
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| Synonym | More Synonyms |
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Kudinoside H BiologicalActivity
| Description | Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1].Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential drug candidate for treating triple-negative breast cancer (TNBC)[2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Apoptosis >>MDM-2/p53 |
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| In Vitro | Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC50 value of 13.96 µM in MDA-MB-231 cells[2]. Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM[2]. Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression[2]. Cell Viability Assay[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM Incubation Time: 24 hours Result: Showed cytotoxicity on MDA-MB-231 cells. Cell Cycle Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, and 20 µM Incubation Time: 24 hours Result: Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, and 20 µM Incubation Time: 24 hours Result: Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. |
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| References | [1]. Kim YH, et al. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient. Biosci Biotechnol Biochem. 2008 Feb;72(2):303-11. Epub 2008 Feb 7. [2]. Zhu X, et al. Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1903 |
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Chemical & Physical Properties
| Density | 1.35 |
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| Boiling Point | 841.9±65.0 °C at 760 mmHg |
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| Melting Point | 198-202ºC |
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| Molecular Formula | C41H66O13 |
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| Molecular Weight | 766.955 |
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| Flash Point | 247.2±27.8 °C |
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| Exact Mass | 766.450317 |
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| PSA | 215.83000 |
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| LogP | 6.59 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.610 |
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| InChIKey | WCHBFWOEFOZHMK-MLHVESHNSA-N |
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| SMILES | CC1CCC2(C(=O)OC3OC(CO)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC43C)C2C1(C)O |
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| Storage condition | 2-8°C |
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Synonyms
| 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester |
| Kudinoside H |
| ziyu-glycoside |
| 1-O-[(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxy-28-oxours-12-en-28-yl]-β-D-glucopyranose |
| ziyu-glycoside I |
| ziyuglucoside I |
| β-D-Glucopyranose, 1-O-[(3β)-3-(α-L-arabinopyranosyloxy)-19-hydroxy-28-oxours-12-en-28-yl]- |
| Gouguside 7 |
| Zigu-glucoside I |
