CAS 1953-54-4|5-Indolol
| Common Name | 5-Indolol | ||
|---|---|---|---|
| CAS Number | 1953-54-4 | Molecular Weight | 133.147 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 343.2±15.0 °C at 760 mmHg |
| Molecular Formula | C8H7NO | Melting Point | 105-110ºC |
| MSDS | ChineseUSA | Flash Point | 161.4±20.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1H-indol-5-ol |
|---|---|
| Synonym | More Synonyms |
5-Indolol BiologicalActivity
| Description | 5-Hydroxyindole, a hydroxylated indole, can be found in a vast array of pharmacologically active agents and natural products. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Kooyman AR, et, al. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells. Br J Pharmacol. 1993 Feb;108(2):287-9. [2]. LaPorte M, et, al. 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition. J Org Chem. 2013 Jan 4;78(1):167-74. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 343.2±15.0 °C at 760 mmHg |
| Melting Point | 105-110ºC |
| Molecular Formula | C8H7NO |
| Molecular Weight | 133.147 |
| Flash Point | 161.4±20.4 °C |
| Exact Mass | 133.052765 |
| PSA | 36.02000 |
| LogP | 0.97 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.739 |
| InChIKey | LMIQERWZRIFWNZ-UHFFFAOYSA-N |
| SMILES | Oc1ccc2[nH]ccc2c1 |
| Storage condition | 0-6°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,453,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01920
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NM2430000 |
| HS Code | 29339990 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 5-hydroxyindol |
| 5-Hydroxyindole,5-Indolol |
| 5-hydroxy-1H-indol |
| EINECS 217-782-6 |
| 1H-Indol-5-ol |
| 5-Hydroxy-1H-indole |
| INDOL-5-OL |
| 1H-indole-5-ol |
| Hydroxy-5-indole |
| 5-Indolol |
| 5-hydroxylindole |
| 5-hydroxy-indole |
| 5-Hydroxyindole |
| MFCD00005677 |
| MFCD0005677 |
