CAS 511-05-7|12-Hydroxyabieta-8(14),9(11),12-trien-7-one
Introduction：Basic information about CAS 511-05-7|12-Hydroxyabieta-8(14),9(11),12-trien-7-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 12-Hydroxyabieta-8(14),9(11),12-trien-7-one | ||
|---|---|---|---|
| CAS Number | 511-05-7 | Molecular Weight | 300.435 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 437.2±45.0 °C at 760 mmHg |
| Molecular Formula | C20H28O2 | Melting Point | / |
| MSDS | / | Flash Point | 186.4±21.3 °C |
Names
| Name | sugiol |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/ImmunologySignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>MAPK/ERK Pathway >>JNKSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | ERK1 ERK2 p38 MAPK JNK1 JNK2 IL-1β |
| In Vitro | Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。 Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。 Western Blot Analysis[1] Cell Line: J774A.1 macrophages cells stimulated with LPS Concentration: 5 μM, 10 μM, 20 μM, and 30 μM Incubation Time: 30 min Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation. |
| References | [1]. Chao KP, et al. Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark. Planta Med. 2005 Apr;71(4):300-5. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.2±45.0 °C at 760 mmHg |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.435 |
| Flash Point | 186.4±21.3 °C |
| Exact Mass | 300.208923 |
| PSA | 37.30000 |
| LogP | 6.77 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.539 |
| InChIKey | IPEHJNRNYPOFII-AZUAARDMSA-N |
| SMILES | CC(C)c1cc2c(cc1O)C1(C)CCCC(C)(C)C1CC2=O |
Safety Information
| Hazard Codes | Xi |
|---|
Synonyms
| 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS,10aS)- |
| 12-Hydroxyabieta-8,11,13-triene-7-one |
| 7-oxo-8,11,13-abietatrien-12-ol |
| 12-Hydroxy-abieta-8,11,13-trien-7-on |
| 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS-trans)- |
| Podocarpa-8,11,13-trien-7-one, 12-hydroxy-13-isopropyl- |
| 12-hydroxy-abieta-8,11,13-trien-7-one |
| 12-Hydroxyabieta-8(14),9(11),12-trien-7-one |
| 10-Deoxoxanthoperol |
| 12-hidroxyabieta-8,11,13-trien-7-one |
