CAS 1501-84-4|Rimantadine Hydrochloride
Introduction：Basic information about CAS 1501-84-4|Rimantadine Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rimantadine Hydrochloride | ||
|---|---|---|---|
| CAS Number | 1501-84-4 | Molecular Weight | 215.763 |
| Density | / | Boiling Point | 247.8ºC at 760mmHg |
| Molecular Formula | C12H22ClN | Melting Point | 300ºC |
| MSDS | ChineseUSA | Flash Point | 99.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Rimantadine Hydrochloride |
|---|---|
| Synonym | More Synonyms |
Rimantadine Hydrochloride BiologicalActivity
| Description | Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
| References | [1]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82. [2]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78. |
Chemical & Physical Properties
| Boiling Point | 247.8ºC at 760mmHg |
|---|---|
| Melting Point | 300ºC |
| Molecular Formula | C12H22ClN |
| Molecular Weight | 215.763 |
| Flash Point | 99.3ºC |
| Exact Mass | 215.144073 |
| PSA | 26.02000 |
| LogP | 4.05230 |
| Vapour Pressure | 0.0251mmHg at 25°C |
| InChIKey | OZBDFBJXRJWNAV-UHFFFAOYSA-N |
| SMILES | CC(N)C12CC3CC(CC(C3)C1)C2.Cl |
| Water Solubility | Freely soluble in water. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 640 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 28(9),23,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,798,1977
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU4717000 |
| HS Code | 2921199090 |
Customs
| HS Code | 2921300090 |
|---|---|
| Summary | 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| 1-(1-Adamantyl)ethylamine Hydrochloride |
| tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride |
| 1-(Adamantan-1-yl)ethanamine hydrochloride (1:1) |
| a-Methyltricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride |
| Roflual |
| 1-(tricyclo[3.3.1.1]dec-1-yl)ethanamine hydrochloride (1:1) |
| Meradan |
| Tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride (1:1) |
| α-Methyl-1-adamantanemethylamine hydrochloride |
| MFCD00072023 |
| UNII:JEI07OOS8Y |
| a-Methyl-1-adamantanemethylamine Hydrochloride |
| 1-(Adamantan-1-yl)ethanamine hydrochloride |
| 1-Tricyclo[3.3.1.1]dec-1-ylethanaminhydrochlorid |
| Alpha-Methyl-1-Adamantanemethylamine Hydrochloride |
| 1-(1-Aminoethyl)adamantane hydrochloride |
| Tricyclo[3.3.1.13,7]-decane-1-methanamine, .α.-methyl-, hydrochloride |
| Rimantadine Hydrochloride |
| 1-tricyclo[3.3.1.1]déc-1-yléthanamine chlorhydrate |
| 1-tricyclo[3.3.1.1]dec-1-ylethanamine hydrochloride |
| Remantadine hydrochloride |
