CAS 42116-76-7|Carnidazole

Introduction：Basic information about CAS 42116-76-7|Carnidazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Carnidazole BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles6
8. Synonyms

Common Name	Carnidazole
CAS Number	42116-76-7	Molecular Weight	244.271
Density	1.4±0.1 g/cm3	Boiling Point	422.8±51.0 °C at 760 mmHg
Molecular Formula	C₈H₁₂N₄O₃S	Melting Point	/
MSDS	ChineseUSA	Flash Point	209.5±30.4 °C
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	O-methyl N-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]carbamothioate
Synonym	More Synonyms

Carnidazole BiologicalActivity

Description	Carnidazole is an antiprotozoal agent of the nitroimidazole class. Carnidazole is used for the research of Trichomonas infection[1].
Related Catalog	Research Areas >>Infection
Target	Antiprotozoal[1]
References	[1]. A Notowicz, et al. First Experiences With Single-Dose Treatment of Vaginal Trichomoniasis With Carnidazole (R 25831). Br J Vener Dis. 1977 Apr;53(2):129-31.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	422.8±51.0 °C at 760 mmHg
Molecular Formula	C₈H₁₂N₄O₃S
Molecular Weight	244.271
Flash Point	209.5±30.4 °C
Exact Mass	244.063004
PSA	116.99000
LogP	0.72
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.627
InChIKey	OVEVHVURWWTPFC-UHFFFAOYSA-N
SMILES	COC(=S)NCCn1c([N+](=O)[O-])cnc1C
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD3912000

CHEMICAL NAME :: Carbamothioic acid, (2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-, O-methyl ester

CAS REGISTRY NUMBER :: 42116-76-7

BEILSTEIN REFERENCE NO. :: 0620260

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H12-N4-O3-S

MOLECULAR WEIGHT :: 244.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 213 umol/L

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 3,51,1983

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H317-H318
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	C
RIDADR	NONH for all modes of transport
RTECS	FD3912000
HS Code	2933290090

Customs

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles6

Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 988 , 187-94, (2015)

A selective, sensitive and high performance liquid chromatography-tandem mass spectrometry (LC-(ESI)MS/MS) method has been developed and validated for the quantification of the potent antitubercular d...

In vitro nitroimidazole resistance of Trichomonas gallinae and successful therapy with an increased dosage of ronidazole in racing pigeons (Columba livia domestica).

J. Vet. Pharmacol. Ther. 15(4) , 409-15, (1992)

Six out of eight different Trichomonas gallinae strains isolated from racing pigeons proved to be resistant to the nitroimidazole drugs ronidazole, carnidazole and metronidazole. The minimal cytocidal...

Structural characterization of drugs and oxygenated metabolites by laser microprobe mass spectrometry (LAMMA).

Biomed. Environ. Mass Spectrom. 16(1-12) , 121-9, (1988)

Laser microprobe mass analysis (LAMMA) was used for the structural characterization of polyfunctional drugs and their oxygenated metabolites, in particular the N-oxides. The spectra usually yield the ...

Synonyms

ME 108

Spartrix

Carnidazole

[2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl]carbamothioic Acid O-Methyl Ester

Carbamothioic acid, N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-, O-methyl ester

O-Methyl [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]carbamothioate

EINECS 255-663-0

UNII-RH5KI819JG

Recommended......