CAS 68506-86-5|Vigabatrin
| Common Name | Vigabatrin | ||
|---|---|---|---|
| CAS Number | 68506-86-5 | Molecular Weight | 129.157 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 277.7±28.0 °C at 760 mmHg |
| Molecular Formula | C6H11NO2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 121.7±24.0 °C |
Names
| Name | Vigabatrin |
|---|---|
| Synonym | More Synonyms |
Vigabatrin BiologicalActivity
| Description | Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.IC50 value:Target: GABA transaminaseClinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. The mode of action is increasing concentrations of the inhibitory neurotransmitter GABA in the brain.A significant increase in seizure threshold was observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of vigabatrin. Bilateral microinjection of vigabatrin (10 μg) into either the anterior or posterior SNr also increased seizure threshold, but less markedly than systemic treatment. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorResearch Areas >>Neurological Disease |
| References | [1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [2]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [3]. Russo, et al. Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity. Behavioural Brain Research (2011), 225(1), 373-376. [4]. Vigabatrin |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 277.7±28.0 °C at 760 mmHg |
| Molecular Formula | C6H11NO2 |
| Molecular Weight | 129.157 |
| Flash Point | 121.7±24.0 °C |
| Exact Mass | 129.078979 |
| PSA | 63.32000 |
| LogP | -0.10 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.483 |
| InChIKey | PJDFLNIOAUIZSL-UHFFFAOYSA-N |
| SMILES | C=CC(N)CCC(=O)O |
| Storage condition | 2-8℃ |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | MP7745000 |
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Synonyms
| UNII:GR120KRT6K |
| vigabatrinum [INN_la] |
| (±)-γ-Vinyl-GABA |
| vigabatrine |
| Vigabatrin |
| vigabatrinum |
| 4-Aminohex-5-enoic acid |
| Sabril |
| vigabatrina |
| 4-Amino-5-hexenoic acid |
| 5-Hexenoic acid, 4-amino- |
