CAS 200933-27-3|Triapine

Introduction：Basic information about CAS 200933-27-3|Triapine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameTriapine
CAS Number200933-27-3Molecular Weight195.245
Density1.46Boiling Point436.0±55.0 °C at 760 mmHg
Molecular FormulaC7H9N5SMelting Point/
MSDS/Flash Point217.5±31.5 °C

Names

Name(2E)-2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
SynonymMore Synonyms

Triapine BiologicalActivity

Description(E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis
In Vitro3-AP shows anti-proliferative activity with IC50 values of 1.3, 1.6 µM for L1210, L1210/HUr cells, respectively[1]. 3-AP (5, 10, 15, 20, 30 mg/kg; i.p.; twice daily for six consecutive days) significantly increases in life span were observed with each dosage employed and long term survivors[1].
References

[1]. Finch RA, et al. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul. 1999;39:3-12.

[2]. Enyedy ÉA ,et al. Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Trans. 2020 Dec 8;49(46):16887-16902.

Chemical & Physical Properties

Density1.46
Boiling Point436.0±55.0 °C at 760 mmHg
Molecular FormulaC7H9N5S
Molecular Weight195.245
Flash Point217.5±31.5 °C
Exact Mass195.057861
PSA125.95000
LogP0.98
Vapour Pressure0.0±1.0 mmHg at 25°C
Index of Refraction1.720
Storage condition-20℃

Synonyms

2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide
Triapine
Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-
2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
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