Introduction：Basic information about CAS 9005-49-6|Heparin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Heparin |
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| CAS Number | 9005-49-6 | Molecular Weight | 1134.93000 |
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| Density | 2.18 g/cm3 | Boiling Point | 644.9ºC at 760mmHg |
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| Molecular Formula | C26H42N2O37S5 | Melting Point | / |
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| MSDS | / | Flash Point | 343.8ºC |
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Names
| Name | Heparin |
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| Synonym | More Synonyms |
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Heparin BiologicalActivity
| Description | Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>OthersNatural Products >>Saccharides and Glycosides |
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| Target | Human Endogenous Metabolite |
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| In Vitro | Heparin is a potent anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin and the structurally related heparan sulfate are complex linear polymers comprised of a mixture of chains of different length, having variable sequences. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin and heparan sulfate predominantly exhibit linear helical secondary structures with sulfo and carboxyl groups displayed at defined intervals and in defined orientations along the polysaccharide backbone. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization[1]. |
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| References | [1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412. |
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Chemical & Physical Properties
| Density | 2.18 g/cm3 |
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| Boiling Point | 644.9ºC at 760mmHg |
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| Molecular Formula | C26H42N2O37S5 |
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| Molecular Weight | 1134.93000 |
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| Flash Point | 343.8ºC |
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| Exact Mass | 1134.01000 |
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| PSA | 652.39000 |
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| Index of Refraction | 1.711 |
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| Water Solubility | H2O: 50 mg/mL, clear, faintly yellow |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MI0700000
- CHEMICAL NAME :
- Heparin
- CAS REGISTRY NUMBER :
- 9005-49-6
- LAST UPDATED :
- 199706
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 1857 units/kg/13D-I
- TOXIC EFFECTS :
- Cardiac - other changes Nutritional and Gross Metabolic - changes in potassium
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1000 units/kg/5D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - changes in potassium
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3536 units/kg/13D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - changes in potassium
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 420 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1900 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 2857 units/kg
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - other effects on male
MUTATION DATA - TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - guinea pig Bone marrow
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 16,196,1970 *** REVIEWS *** TOXICOLOGY REVIEW AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 52,375,1975 TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,517,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84488 No. of Facilities: 374 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 4525 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84488 No. of Facilities: 430 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 27273 (estimated) No. of Female Employees: 23149 (estimated)
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Safety Information
| Safety Phrases | 24/25 |
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| WGK Germany | 2 |
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| RTECS | MI0850000 |
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| HS Code | 3001901000 |
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Customs
Synonyms
| clarin |
| thrombophob |
| HED heparin |
| liquaemin |
| Enoxaparine |
| pularin |
| Depo heparin |
| MFCD00081689 |
| EINECS 232-681-7 |
