CAS 120205-48-3|(3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester
Introduction：Basic information about CAS 120205-48-3|(3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride | ||
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| CAS Number | 120205-48-3 | Molecular Weight | 295.846 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H30ClNO3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino) heptanoate hydrochloride (1:1) |
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| Synonym | More Synonyms |
BiologicalActivity
| Description | Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| References | [1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. |
Chemical & Physical Properties
| Molecular Formula | C14H30ClNO3 |
|---|---|
| Molecular Weight | 295.846 |
| Exact Mass | 295.191437 |
| PSA | 47.56000 |
| LogP | 3.56020 |
| InChIKey | JRXGCIIOQALIMZ-LWEGJDAASA-N |
| SMILES | CCC(C)C(NC)C(CC(=O)OC(C)(C)C)OC.Cl |
Synonyms
| tert-butyl trans(+-)-4-amino-3-hydroxypiperidine-1-carboxylate |
| Heptanoic acid, 3-methoxy-5-methyl-4-(methylamino)-, 1,1-dimethylethyl ester, (3R,4S,5S)-, hydrochloride (1:1) |
| (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol |
| (3R,4R)-N-tert-butoxycarbonyl-3-hydroxy-4-hydroxymethylpyrrolidine |
| 2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride (1:1) |
| tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride |
| (3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride |
| N-tert-butoxycarbonyl-(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine |
| tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate |
| tert-butyl (3R,4S)-3-amino-4-hydroxy-azepan-1-carboxylate |
| (3R,4R)-1-tert-butoxycarbonyl-3-hydroxy-4-(hydroxymethyl)pyrrolidine |
| Dil tert-butyl ester hydrochloride |
| tert-butyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride |
| (3R,4R)-tert-butyl 3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate |
| H-Dil-OtBu.HCl |
| (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidin-1-N-carboxylic acid tert-butyl ester |
| (3R,4S,5S)-Dil-OBu-t*HCl |
| (3R,4S)-3-Amino-4-hydroxy-azepane-1-carboxylic acid tert-butyl ester |
| tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate |
| (3R,4S,5S)-3-methoxy-5-methyl-4-methylamino-heptanoic acid tert-butyl ester hydrochloride |
| (3R,4S,5S)-tert-butyl 3-methoxy-5-methyl-4-(methylamino)heptanoatehydrochloride |
| Diltiazem hydrochloride |
| (3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride |
