CAS 142457-00-9|Amthamine dihydrobromide
| Common Name | Amthamine dihydrobromide | ||
|---|---|---|---|
| CAS Number | 142457-00-9 | Molecular Weight | 319.06 |
| Density | / | Boiling Point | / |
| Molecular Formula | C6H13Br2N3S | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine,dihydrobromide |
|---|---|
| Synonym | More Synonyms |
Amthamine dihydrobromide BiologicalActivity
| Description | Amthamine is a histamine receptor (H1R-H4R) agonist. Amthamine can produce liver congestion and necrosis of liver cells. Amthamine can be used to study the induction effect of H1R-H4 agonist on hepatotoxicity [1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| References | [1]. Trivendra Tripathi, et al. Hepatotoxicity Due to Histamine Trifluoro-Methyl Toluidide, Amthamine, R-(-)-α-Methyl Histamine and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental Model. American Medical Journal. 2010, 1 (1): 1-7. |
Chemical & Physical Properties
| Molecular Formula | C6H13Br2N3S |
|---|---|
| Molecular Weight | 319.06 |
| Exact Mass | 316.92000 |
| PSA | 93.90000 |
| LogP | 3.08150 |
| InChIKey | XFXNNOPUDSFVJE-UHFFFAOYSA-N |
| SMILES | Br.Br.Cc1nc(N)sc1CCN |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles27
More Articles| Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists. Pharmacol. Rep. 62(5) , 917-25, (2010) The present study was designed to delineate the immunomodulatory role of histamine receptors (H1R and H2R) and their antibody generation in a rabbit model. Six groups containing 18 rabbits each receiv... | |
| Analysis of the histamine H2-receptor in human monocytes. Biochem. Pharmacol. 92(2) , 369-79, (2014) Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-c... | |
| Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis. Clin. Sci. 127(7) , 435-48, (2014) Histamine H2 receptor (H2R) blockade has been reported to be beneficial for patients with chronic heart failure (CHF), but the mechanisms involved are not entirely clear. In the present study, we asse... |
Synonyms
| cc-388 |
| Amthamine dihydrobromide |
| Hispidulin |
| 2-amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide |
| 2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide |
