CAS 128700-97-0|Gingerenone A

Introduction：Basic information about CAS 128700-97-0|Gingerenone A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Gingerenone A BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Gingerenone A
CAS Number	128700-97-0	Molecular Weight	356.41
Density	1.183g/cm3	Boiling Point	571.3ºC at 760mmHg
Molecular Formula	C₂₁H₂₄O₅	Melting Point	/
MSDS	/	Flash Point	200.3ºC

Names

Name	(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one
Synonym	More Synonyms

Gingerenone A BiologicalActivity

Description	Gingerenone A is a Nrf2-Gpx4 activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale[1][2].
Related Catalog	Signaling Pathways >>NF-κB >>Keap1-Nrf2Research Areas >>Inflammation/Immunology
Target	Nrf2-Gpx4[1]
References	[1]. Yu TJ, et al. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Antioxidants (Basel). 2022 Mar 19;11(3):587. [2]. Chen Y, et al. Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway. J Agric Food Chem. 2022 Oct 5;70(39):12525-12534.

Chemical & Physical Properties

Density	1.183g/cm3
Boiling Point	571.3ºC at 760mmHg
Molecular Formula	C₂₁H₂₄O₅
Molecular Weight	356.41
Flash Point	200.3ºC
Exact Mass	356.16200
PSA	75.99000
LogP	3.80570
Vapour Pressure	1.19E-13mmHg at 25°C
Index of Refraction	1.583
InChIKey	FWDXZNKYDTXGOT-GQCTYLIASA-N
SMILES	COc1cc(CCC=CC(=O)CCc2ccc(O)c(OC)c2)ccc1O
Storage condition	2-8 °C

Synonyms

(E)-gingerenone A

(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one

Y7369

gingerenone-A

1,7-bis(4-hydroxy-3-methoxyphenyl)-hept-4-en-3-one

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