CAS 155453-10-4|Tiludronate disodium hemihydrate
Introduction：Basic information about CAS 155453-10-4|Tiludronate disodium hemihydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tiludronate disodium hemihydrate | ||
|---|---|---|---|
| CAS Number | 155453-10-4 | Molecular Weight | 743.15900 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H16Cl2Na4O13P4S2 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | tetrasodium,[(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate,hydrate |
|---|---|
| Synonym | More Synonyms |
Tiludronate disodium hemihydrate BiologicalActivity
| Description | Tiludronate (Tiludronic Acid) disodium hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodium hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodium hemihydrate is a potent inhibitor of the osteoclast vacuolar H+-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Proton Pump |
| In Vitro | The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC50=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC50=466 nM). Tiludronate also potently inhibited proton transport in yeast microsomal preparations (IC50=3.5 microM) and inhibited the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible[3]. |
| In Vivo | Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content[3]. |
| References | [1]. Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989;2(8678-8679):1469-1471. [2]. Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018;89(1):105-116. [3]. Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17(5 Suppl):473S-477S. [4]. David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res. 1996;11(10):1498-1507. |
Chemical & Physical Properties
| Molecular Formula | C14H16Cl2Na4O13P4S2 |
|---|---|
| Molecular Weight | 743.15900 |
| Exact Mass | 741.79500 |
| PSA | 340.51000 |
| LogP | 5.83070 |
| InChIKey | KDVKAYPVWJFARG-UHFFFAOYSA-J |
| SMILES | O.O=P([O-])(O)C(Sc1ccc(Cl)cc1)P(=O)([O-])O.O=P([O-])(O)C(Sc1ccc(Cl)cc1)P(=O)([O-])O.[Na+].[Na+].[Na+].[Na+] |
Synonyms
| Phosphonic acid,(((4-chlorophenyl)thio)methylene)bis-,disodium salt,hydrate (2:1) |
| UNII-39SMX0W5WK |
| P,P'-(((4-Chlorophenyl)thio)methylene)bisphosphonic acid,disodium hemihydrate |
| Tiludronic acid disodium salt hemihydrate [MI] |
| Tiludronate disodium hemihydrate |
