Introduction：Basic information about CAS 155584-74-0|VUF 10166, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | VUF 10166 |
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| CAS Number | 155584-74-0 | Molecular Weight | 262.738 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 389.6±42.0 °C at 760 mmHg |
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| Molecular Formula | C13H15ClN4 | Melting Point | / |
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| MSDS | / | Flash Point | 189.4±27.9 °C |
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Names
| Name | 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline |
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| Synonym | More Synonyms |
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VUF 10166 BiologicalActivity
| Description | VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT3A Receptor:0.04 nM (Ki) 5-HT 3 AB:22 nM (Ki) |
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| References | [1]. Thompson AJ, et al. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J Pharmacol Exp Ther. 2012 May;341(2):350-9. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 389.6±42.0 °C at 760 mmHg |
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| Molecular Formula | C13H15ClN4 |
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| Molecular Weight | 262.738 |
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| Flash Point | 189.4±27.9 °C |
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| Exact Mass | 262.098511 |
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| PSA | 32.26000 |
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| LogP | 2.79 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.637 |
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| InChIKey | FFXVTQDGTKEXHF-UHFFFAOYSA-N |
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| SMILES | CN1CCN(c2nc3ccccc3nc2Cl)CC1 |
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| Storage condition | -20°C |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)- |
| Quinoxaline (2-chloro-3-(4-methyl-1-piperazinyl) |
| 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline |
| VUF 10166 |
