Introduction：Basic information about CAS 21516-68-7|monascin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | monascin |
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| CAS Number | 21516-68-7 | Molecular Weight | 358.42800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H26O5 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | monascin |
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| Synonym | More Synonyms |
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monascin BiologicalActivity
| Description | Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor)[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vivo | Monascin (0.0025% in drinking water; mice) appears effective for the inhibition of UVB-initiated carcinogenesis on mouse skin[1]. Animal Model: SENCAR mouse using a UVB irradiation as an initiator and TPA as a promoter[1]. Dosage: 0.0025% in drinking water. Administration: Orally daily for 2 weeks in drinking water. Result: Reduced the number of the papillomas. |
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| References | [1]. Akihisa T, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice). Chem Biodivers. 2005 Oct;2(10):1305-9. [2]. Lee CL, et al. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006 Oct;72(6):1254-62. |
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Chemical & Physical Properties
| Molecular Formula | C21H26O5 |
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| Molecular Weight | 358.42800 |
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| Exact Mass | 358.17800 |
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| PSA | 69.67000 |
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| LogP | 3.44330 |
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| InChIKey | XXKNHBAFFJINCK-RVEJDSBJSA-N |
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| SMILES | CC=CC1=CC2=C(CO1)C(=O)C1(C)OC(=O)C(C(=O)CCCCC)C1C2 |
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| Storage condition | 2-8°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| Monascoflavin |
| Monascin |
| (3S,3aR,9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]-3,3a,4,8-tetrahydrofuro[3,2-g]isochromene-2,9-dione |
| monascusone B |
