CAS 83461-56-7|Mifamurtide

Introduction：Basic information about CAS 83461-56-7|Mifamurtide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Mifamurtide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles27
6. Synonyms

Common Name	Mifamurtide
CAS Number	83461-56-7	Molecular Weight	1237.499
Density	1.2±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₅₉H₁₀₉N₆O₁₉P	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	mifamurtide
Synonym	More Synonyms

Mifamurtide BiologicalActivity

Description	Mifamurtide(CGP19835; MTP-PE) is a drug against osteosarcoma.Target: OthersMifamurtide is an immunomodulator with antitumor effects that appear to be mediated via activation of monocytes and macrophages. Mifamurtide is generally well tolerated; adverse events attributed to administration of the drug include chills, fever, headache, nausea, and myalgias. Based on the available data, mifamurtide can be considered for inclusion in treatment protocols for localized osteosarcoma [1]. Mifamurtide has orphan drug status for the treatment of osteosarcoma in the US and EU [2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>Cancer
References	[1]. Frampton, J.E., Mifamurtide: a review of its use in the treatment of osteosarcoma. Paediatr Drugs, 2010. 12(3): p. 141-53. [2]. Mifamurtide: CGP 19835, CGP 19835A, L-MTP-PE, liposomal MTP-PE, MLV 19835A, MTP-PE, muramyltripeptide phosphatidylethanolamine. Drugs R D, 2008. 9(2): p. 131-5.

Description

Mifamurtide(CGP19835; MTP-PE) is a drug against osteosarcoma.Target: OthersMifamurtide is an immunomodulator with antitumor effects that appear to be mediated via activation of monocytes and macrophages. Mifamurtide is generally well tolerated; adverse events attributed to administration of the drug include chills, fever, headache, nausea, and myalgias. Based on the available data, mifamurtide can be considered for inclusion in treatment protocols for localized osteosarcoma [1]. Mifamurtide has orphan drug status for the treatment of osteosarcoma in the US and EU [2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>Cancer

References

[1]. Frampton, J.E., Mifamurtide: a review of its use in the treatment of osteosarcoma. Paediatr Drugs, 2010. 12(3): p. 141-53.

[2]. Mifamurtide: CGP 19835, CGP 19835A, L-MTP-PE, liposomal MTP-PE, MLV 19835A, MTP-PE, muramyltripeptide phosphatidylethanolamine. Drugs R D, 2008. 9(2): p. 131-5.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Molecular Formula	C₅₉H₁₀₉N₆O₁₉P
Molecular Weight	1237.499
Exact Mass	1236.748535
PSA	385.91000
LogP	10.98
Index of Refraction	1.530
Storage condition	2-8℃

Safety Information

Articles27

Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma.

Expert Rev. Anticancer Ther. 9(8) , 1035-49, (2009)

Osteosarcoma is an ultraorphan disease. There are approximately 1000 new patients diagnosed with osteosarcoma each year in the USA and Europe. Current treatment for osteosarcoma utilizes multiagent ch...

Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole.

Parasitol. Res. 103(4) , 919-29, (2008)

The effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) administered separately or with anthelmintic albendazole (ABZ) on cellular immunity of mice with alveolar echinococcosis...

In vitro and in vivo enhancement of canine pulmonary alveolar macrophage cytotoxic activity against canine osteosarcoma cells.

Cancer Biother. Radiopharm. 14(2) , 121-8, (1999)

The combination of chemotherapy with immunotherapy may offer an advantage over either therapy alone and provide a greater potential for total tumor eradication. Monocyte/macrophage-mediated tumor cell...

Synonyms

Mifamurtide

muramyl tripeptide phosphatidylethanolamine

(2R,5S,8R,13S,22R)-2-{[(3R,4R,5S,6R)-3-Acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}-8-carbamoyl-19-hydroxy-5,13-dimethyl-19-oxido-3,6,11,14,25-pentaoxo-18,20,24-trioxa-4,7,12 ;,15-tetraaza-19λ-phosphatetracontan-22-yl hexadecanoate

N-Acetylmuramyl-alanyl-isoglutaminyl-alanyl-sn-glycero-3-phosphoethano lamine

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