CAS 35263-73-1|LHRH (free acid) trifluoroacetate salt
| Common Name | LHRH (free acid) trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 35263-73-1 | Molecular Weight | 1183.27 |
| Density | 1.54 g/cm3 | Boiling Point | / |
| Molecular Formula | C55H74N16O14 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | lhrh |
|---|---|
| Synonym | More Synonyms |
LHRH (free acid) trifluoroacetate salt BiologicalActivity
| Description | LHRH, the luteinizing hormone-releasing hormone, is a neuropeptide hypothalamic. LHRH regulates reproduction. LHRH can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GNRH ReceptorResearch Areas >>Endocrinology |
| References | [1]. Schally AV, et, al. Discovery of LHRH and development of LHRH analogs for prostate cancer treatment. Prostate. 2017 Jun;77(9):1036-1054. [2]. Pearce TR, et, al. Peptide targeted lipid nanoparticles for anticancer drug delivery. Adv Mater. 2012 Jul 24;24(28):3803-22, 3710. |
Chemical & Physical Properties
| Density | 1.54 g/cm3 |
|---|---|
| Molecular Formula | C55H74N16O14 |
| Molecular Weight | 1183.27 |
| Exact Mass | 1182.56000 |
| PSA | 466.34000 |
| LogP | 1.00640 |
| Index of Refraction | 1.709 |
| InChIKey | IGACZQNUZMBGFX-AQJXLSMYSA-N |
| SMILES | CC(C)CC(NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)O |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | R60 |
| Safety Phrases | 53-22-36/37/39-45 |
| RIDADR | NONH for all modes of transport |
Articles193
More Articles| Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription by RF-amide-related peptide-3 and kisspeptin in a novel GnRH-secreting cell line, mHypoA-GnRH/GFP. J. Neuroendocrinol. 26(12) , 888-97, (2014) RF-amide-related peptide-3 [RFRP-3; also often referred to as the mammalian orthologue of the avian gonadotrophin-inhibitory hormone (GnIH)] and kisspeptin have emerged as potent modulators of neuroen... | |
| Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation. Mol. Cell. Endocrinol. 402 , 95-106, (2015) Transmembrane helix seven residues of G protein-coupled receptors (GPCRs) couple agonist binding to a conserved receptor activation mechanism. Amino-terminal residues of the GnRH peptide determine ago... | |
| Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study. Reprod. Biomed. Online 30(4) , 340-8, (2015) The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfe... |
Synonyms
| PYR-HWSYGLRPG |
| GONADOTROPIN-RELEASING HORMONE |
| PYR-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY |
| LUTEINIZING HORMONE-RELEASING HORMONE |
| mammalian GnRH I |
| luteinizing hormone releasing hormone free acid |
| pEHWSYGLRPG |
| <Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH > |
| GLP-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY |
| pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH |
