CAS 70142-34-6|Polyoxyl 15 hydroxystearate
| Common Name | Polyoxyl 15 hydroxystearate | ||
|---|---|---|---|
| CAS Number | 70142-34-6 | Molecular Weight | 963.23800 |
| Density | 1.048 g/cm3 at 20 °C | Boiling Point | / |
| Molecular Formula | C47H94O19 | Melting Point | 25-30 °C |
| MSDS | ChineseUSA | Flash Point | 272 ℃ |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 11-hydroxy-17-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]heptadecanoic acid |
|---|---|
| Synonym | More Synonyms |
Polyoxyl 15 hydroxystearate BiologicalActivity
| Description | Polyoxyl 15 hydroxystearate is a nonionic surfactant and emulsifier. Polyoxyl 15 hydroxystearate is used for improving the solubility and dissolution of poorly watersoluble drugs[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Polyoxyl 15 hydroxystearate is found to be effective in enhancing the solubility and stability of Curcumin (HY-N0005)[2]. Polyoxyl 15 hydroxystearate is employed as a carrier to build up a stable CoQ10-loaded micelle delivery system[3]. |
| References | [1]. Cho HJ, et al. Poly(lactic-co-glycolic) Acid/Solutol HS15-Based Nanoparticles for Docetaxel Delivery. J Nanosci Nanotechnol. 2016;16(2):1433‐1436. [2]. Seo SW, et al. Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier. Int J Pharm. 2012;424(1-2):18‐25. [3]. Liu L, et al. Kolliphor® HS 15 Micelles for the Delivery of Coenzyme Q10: Preparation, Characterization, and Stability. AAPS PharmSciTech. 2016;17(3):757-766. |
Chemical & Physical Properties
| Density | 1.048 g/cm3 at 20 °C |
|---|---|
| Melting Point | 25-30 °C |
| Molecular Formula | C47H94O19 |
| Molecular Weight | 963.23800 |
| Flash Point | 272 ℃ |
| Exact Mass | 962.63900 |
| PSA | 216.21000 |
| LogP | 4.13460 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Hazard Codes | Xi |
| Safety Phrases | 24-37 |
| RIDADR | NONH for all modes of transport |
Articles6
More Articles| Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke. Sci. Rep. 5 , 17956, (2015) Cyclooxygenase-2 (COX-2) is activated in response to ischemia and significantly contributes to the neuroinflammatory process. Accumulation of COX-2-derived prostaglandin E2 (PGE2) parallels the substa... | |
| Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance. Cancer Res. 51 , 897-902, (1991) A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance ... | |
| Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results. Int. J. Pharm. 365(1-2) , 143-149, (2009) The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded mic... |
Synonyms
| Polyethylene glycol (15)-hydroxystearate |
| Polyoxyethylated 12-hydroxystearic acid |
| Macrogol (15)-hydroxystearate |
