CAS 117027-34-6|L-LYSYL-D-PROLYL-L-THREONINE

Introduction：Basic information about CAS 117027-34-6|L-LYSYL-D-PROLYL-L-THREONINE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. L-LYSYL-D-PROLYL-L-THREONINE BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	L-LYSYL-D-PROLYL-L-THREONINE
CAS Number	117027-34-6	Molecular Weight	344.41
Density	1.288g/cm3	Boiling Point	691.3ºC at 760mmHg
Molecular Formula	C₁₅H₂₈N₄O₅	Melting Point	/
MSDS	/	Flash Point	371.9ºC

Names

Name	h-lys-d-pro-thr-oh
Synonym	More Synonyms

L-LYSYL-D-PROLYL-L-THREONINE BiologicalActivity

Description	Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Metabolic Disease
Target	IL-1
In Vivo	Lys-D-Pro-Thr (10 mg/kg; 腹腔给药; 持续 4 天) 抑制 fMLP (HY-P0224) 和 MMK-1 (HY-P1117) 对依托泊苷 (HY-13629) 诱导脱发的保护作用[1]。 Animal Model: 11-d-old rats[1] Dosage: 10 mg/kg Administration: IP; for 4 days Result: Inhibited the protective effect of fMLP and that of MMK-1 against Etoposide-induced alopecia. It alone did not induce alopecia.
References	[1]. Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202. [2]. Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11.

Chemical & Physical Properties

Density	1.288g/cm3
Boiling Point	691.3ºC at 760mmHg
Molecular Formula	C₁₅H₂₈N₄O₅
Molecular Weight	344.41
Flash Point	371.9ºC
Exact Mass	344.20600
PSA	158.98000
LogP	0.11330
Vapour Pressure	4.12E-22mmHg at 25°C
Index of Refraction	1.56
InChIKey	LOGFVTREOLYCPF-KXNHARMFSA-N
SMILES	CC(O)C(NC(=O)C1CCCN1C(=O)C(N)CCCCN)C(=O)O

Safety Information

Safety Phrases	22-24/25

Synonyms

l-lysyl-d-prolyl-l-threonine

l-lys-d-pro-l-thr

lys-d-pro-thr

interleukin 1b antagonist

[D-Pro194]-IL-1 b (193-195) (human)

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