Introduction：Basic information about CAS 151-18-8|Z2CN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Z2CN |
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| CAS Number | 151-18-8 | Molecular Weight | 70.093 |
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| Density | 0.9±0.1 g/cm3 | Boiling Point | 186.3±13.0 °C at 760 mmHg |
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| Molecular Formula | C3H6N2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 66.5±19.8 °C |
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Names
| Name | β-aminopropionitrile |
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| Synonym | More Synonyms |
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Z2CN BiologicalActivity
| Description | β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Neuronal Signaling >>Monoamine Oxidase |
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| Target | Human Endogenous Metabolite |
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| In Vitro | β-Aminopropionitrile blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibited invasion and migration capacities of cervical carcinoma cells in vitro[2]. |
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| References | [1]. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51. [2]. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8. |
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Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
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| Boiling Point | 186.3±13.0 °C at 760 mmHg |
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| Molecular Formula | C3H6N2 |
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| Molecular Weight | 70.093 |
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| Flash Point | 66.5±19.8 °C |
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| Exact Mass | 70.053101 |
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| PSA | 49.81000 |
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| LogP | -1.02 |
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| Vapour Pressure | 0.7±0.4 mmHg at 25°C |
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| Index of Refraction | 1.430 |
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| InChIKey | AGSPXMVUFBBBMO-UHFFFAOYSA-N |
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| SMILES | N#CCCN |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UG0350000
- CHEMICAL NAME :
- Propionitrile, 3-amino-
- CAS REGISTRY NUMBER :
- 151-18-8
- BEILSTEIN REFERENCE NO. :
- 1698848
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C3-H6-N2
- MOLECULAR WEIGHT :
- 70.11
- WISWESSER LINE NOTATION :
- Z2CN
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12800 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1152 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg/11D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5 gm/kg
- SEX/DURATION :
- female 14-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1250 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1250 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - mouse Embryo
- DOSE/DURATION :
- 1250 mg/kg
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,305,1981
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Safety Information
| Hazard Codes | Xn:Harmful; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S36/37 |
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| RIDADR | 3276 |
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| RTECS | UG0350000 |
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| Packaging Group | III |
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| Hazard Class | 8 |
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| HS Code | 2926909090 |
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Customs
| HS Code | 2926909090 |
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| Summary | HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 3-Amino-1-propanethiolHCl |
| Propanenitrile, 3-amino- |
| chlorhydrate de mercapto-3 propylamine |
| 3-amino-propionitrile |
| 3-mercapto-1-propylamino hydrochloride |
| 3-Aminopropionitrile |
| 3-Mercaptopropylamine hydrochloride |
| EINECS 205-786-0 |
| MFCD00014820 |
| Z2CN |
| N-(2-Cyanoethyl)amine |
| beta-aminopropionitrile |
| 2-Cyanoethylamine |
| 3-cyanoethylamine |
| 3-aminopropanonitrile |
| 1-Propanethiol,3-aMino-,hydrochloride |
| 3-Aminopropionitrile Fumarate |
| 3-thiopropylamine hydrochloride |
| 3-Aminopropanenitrile |
| aminopropylthiol hydrochloride |
| β-Aminopropionitrile |
| homocysteamine hydrochloride |
| 3-aminopropanethiol hydrochloride |
| aminoethylcyanide |
