Introduction：Basic information about CAS 910297-52-8|Dasatinib N-Oxide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dasatinib N-Oxide |
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| CAS Number | 910297-52-8 | Molecular Weight | 504.00500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H26ClN7O3S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-4-oxidopiperazin-4-ium-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
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| Synonym | More Synonyms |
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Dasatinib N-Oxide BiologicalActivity
| Description | Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2]. |
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| Related Catalog | Research Areas >>Cancer |
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| In Vivo | Dasatinib N-oxide is the pharmacologically active metabolite after oral administration[1]. |
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| References | [1]. Christopher LJ, et, al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36(7):1357-64. [2]. Furlong MT, et, al. A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study. J Pharm Biomed Anal. 2012 Jan 25;58:130-5. |
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Chemical & Physical Properties
| Molecular Formula | C22H26ClN7O3S |
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| Molecular Weight | 504.00500 |
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| Exact Mass | 503.15100 |
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| PSA | 164.43000 |
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| LogP | 3.80690 |
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| InChIKey | UEFNEEZCTQCRAW-UHFFFAOYSA-N |
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| SMILES | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CC[N+]([O-])(CCO)CC2)n1 |
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| Storage condition | -20°C |
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Synonyms
| N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide |
| Dasatinib N-Oxide |
| Dasatinib Impurity 7 |
