CAS 68124-04-9|Chonglou Saponin VII
Introduction：Basic information about CAS 68124-04-9|Chonglou Saponin VII, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chonglou Saponin VII | ||
|---|---|---|---|
| CAS Number | 68124-04-9 | Molecular Weight | 1031.184 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C51H82O21 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Chonglou Saponin VII |
|---|---|
| Synonym | More Synonyms |
Chonglou Saponin VII BiologicalActivity
| Description | Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilyResearch Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKSignaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoproteinSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
| Target | Akt p38 Bcl-2 Caspase-9 Caspase-3 PARP-1 |
| In Vitro | Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase[1]. |
| In Vivo | Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice[2]. |
| References | [1]. Yan T, et al. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907. [2]. Li Y, et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C51H82O21 |
| Molecular Weight | 1031.184 |
| Exact Mass | 1030.534912 |
| PSA | 314.83000 |
| LogP | 4.91 |
| Index of Refraction | 1.629 |
| InChIKey | FBFJAXUYHGSVFN-IYUYFXHASA-N |
| SMILES | CC1CCC2(OC1)OC1CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(C)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C6OC6OC(C)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C1(O)C2C |
| Storage condition | -20℃ |
Synonyms
| (3β,25R)-17-Hydroxyspirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside |
| β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->4)]- |
| Paris saponin VII |
