CAS 126047-75-4|H-Gly-Pro-Arg-Pro-NH2 acetate salt
Introduction：Basic information about CAS 126047-75-4|H-Gly-Pro-Arg-Pro-NH2 acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Gly-Pro-Arg-Pro-NH2 acetate salt | ||
|---|---|---|---|
| CAS Number | 126047-75-4 | Molecular Weight | 424.49800 |
| Density | / | Boiling Point | / |
| Molecular Formula | C18H32N8O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | (2S)-1-(2-aminoacetyl)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
H-Gly-Pro-Arg-Pro-NH2 acetate salt BiologicalActivity
| Description | H-Gly-Pro-Arg-Pro-NH2 is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein. H-Gly-Pro-Arg-Pro-NH2 prevents fibrin polymerization[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| References | [1]. Mosnier LO, et al. Regulation of fibrinolysis in plasma by TAFI and protein C is dependent on the concentration of thrombomodulin. Thromb Haemost. 2001 Jan;85(1):5-11. |
Chemical & Physical Properties
| Molecular Formula | C18H32N8O4 |
|---|---|
| Molecular Weight | 424.49800 |
| Exact Mass | 424.25500 |
| PSA | 200.73000 |
| LogP | 0.01870 |
| InChIKey | SCCTZYGEMPQRCV-AVGNSLFASA-N |
| SMILES | NCC(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(N)=O |
| Storage condition | 20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles6
More Articles| The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion. Protein Sci. 1(12) , 1719-20, (1992) | |
| The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model. J. Thromb. Haemost. 1(3) , 587-94, (2003) Although hirudin is better than heparin at preventing recurrent ischemia in patients with unstable angina, hirudin produces more bleeding. The purpose of this study was to use a rabbit arterial thromb... | |
| Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin. .PubMed ID Members of the Src family of kinases are abundant in platelets. Although their localization is known, their role(s) in platelet function are not well understood. Lyn is a Src-family kinase that partic... |
Synonyms
| Gly-Pro-Arg-Pro amide |
| L-Prolinamide,glycyl-L-prolyl-L-arginyl |
