CAS 35891-93-1|Tocainide HCl

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TX1404500

CHEMICAL NAME :

Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, monohydrochloride

CAS REGISTRY NUMBER :

35891-93-1

LAST UPDATED :

199706

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C11-H16-N2-O.Cl-H

MOLECULAR WEIGHT :

228.75

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

48 mg/kg/2D-I

TOXIC EFFECTS :

Behavioral - hallucinations, distorted perceptions

REFERENCE :

PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 61,79,1985

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

257 mg/kg/15D-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Taste) - change in function Behavioral - tremor Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,142,1988

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

360 mg/kg/6W-I

TOXIC EFFECTS :

Blood - normocytic anemia Blood - agranulocytosis

REFERENCE :

AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 147,598,1987

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

529 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,192,1973