CAS 2062-84-2|Benperidol
Introduction：Basic information about CAS 2062-84-2|Benperidol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benperidol | ||
|---|---|---|---|
| CAS Number | 2062-84-2 | Molecular Weight | 381.44 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C22H24FN3O2 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Benperidol |
|---|---|
| Synonym | More Synonyms |
Benperidol BiologicalActivity
| Description | Benperidol is a relatively old antipsychotic drug. Benperidol is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| References | [1]. Leucht S, et al. Benperidol for schizophrenia. Cochrane Database Syst Rev. 2005;2005(2):CD003083. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H24FN3O2 |
| Molecular Weight | 381.44 |
| Exact Mass | 381.185242 |
| PSA | 58.10000 |
| LogP | 4.09 |
| Vapour Pressure | 7.96E-17mmHg at 25°C |
| Index of Refraction | 1.595 |
| InChIKey | FEBOTPHFXYHVPL-UHFFFAOYSA-N |
| SMILES | O=C(CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Autonomic Nervous System - central sympatholytic Behavioral - alteration of classical conditioning
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 432 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 204 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 192 umol/kg
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,231,1984
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 192 umol/kg
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,231,1984
Articles25
More Articles| Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates. Eur. J. Nucl. Med. Mol. Imaging 35(4) , 771-8, (2008) N-([(11)C]methyl)benperidol ([(11)C]NMB) can be used for positron emission tomography (PET) measurements of D(2)-like dopamine receptor binding in vivo. We report the absorbed radiation dosimetry of i... | |
| Radiation dosimetry of [18F] (N-methyl)benperidol as determined by whole-body PET imaging of primates. Nucl. Med. Biol. 24(4) , 311-8, (1997) Radiation absorbed doses due to IV administration of [18F](N-methyl) benperidol ([18F]NMB) were estimated by whole-body PET imaging of nonhuman primates. Time-activity curves were obtained for nine co... | |
| Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans. Nucl. Med. Biol. 35(3) , 335-41, (2008) Positron emission tomography measurements of dopaminergic D2-like receptors may provide important insights into disorders such as Parkinson's disease, schizophrenia, dystonia and Tourette's syndrome. ... |
Synonyms
| 1-[1-[4-(p-Fluorophenyl)-4-oxobutyl]piperidin-4-yl]-2-benzimidazolinone |
| R 4584 |
| 1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-2-benzimidazolinone |
| 2H-Benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl)-1,3-dihydro- |
| EINECS 218-172-2 |
| 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one |
| 1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one |
| Frenactil |
| Benzeridol |
| Benperidol |
| MFCD00866672 |
| Glianimon |
| Anquil |
| 2H-Benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro- |
| Frenactyl |
| 8089c.b. |
| Concilium |
| 1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one |
